{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:23Z","timestamp":1788671543447,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. 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Participants were grouped as placebo, gantenerumab\u2010treated without ARIA, or gantenerumab\u2010treated with ARIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Gantenerumab treatment was associated with greater parenchymal volume reduction than placebo, with no difference between ARIA and non\u2010ARIA groups. The ARIA group exhibited greater ventricular enlargement which was offset by reduced external cerebrospinal fluid space expansion. Greater amyloid removal correlated with greater volume reduction, although volume changes also occurred in white matter, where amyloid is minimal. Furthermore, the ARIA group showed a flatter relationship between ventricular expansion and clinical decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>ARIA are not associated with long\u2010term parenchymal reduction; rather, they are linked to a fluid shift from the external space to the ventricles. Amyloid removal correlates with parenchymal changes, but white matter changes suggest additional mechanisms beyond local clearance. Neither phenomenon was associated with worse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>NCT03444870 and NCT03443973<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71749","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:24:26Z","timestamp":1786699466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Volume change with gantenerumab: Impact of amyloid\u2010related imaging abnormalities and amyloid removal"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-5710","authenticated-orcid":false,"given":"Matteo","family":"Tonietto","sequence":"first","affiliation":[{"name":"Neuroscience and Rare Diseases Roche Pharma Early Research and Development, F. Hoffmann\u2010La Roche Ltd  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Neuroscience and Rare Diseases Roche Pharma Early Research and Development, F. Hoffmann\u2010La Roche Ltd  Basel Switzerland"},{"name":"A4P Consulting Ltd.  Sandwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R. S.","family":"Belder","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurology Royal Adelaide Hospital and Queen Elizabeth Hospital  Adelaide South Australia Australia"},{"name":"School of Medicine Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Radiology &amp; Nuclear Medicine Amsterdam UMC, Vrije Universiteit  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick C.","family":"Fox","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Smith","sequence":"additional","affiliation":[{"name":"Roche Products Ltd  Welwyn Garden City UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Klein","sequence":"additional","affiliation":[{"name":"Neuroscience and Rare Diseases Roche Pharma Early Research and Development, F. 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