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At age 67 we assayed plasma AD\u2010related biomarkers (phosphorylated tau [p\u2010tau]217, neurofilament light chain [NfL], amyloid beta (A\u03b2)42\/40 ratio, and glial fibrillary acidic protein [GFAP]). We used generalized estimating equations to test whether PA at ages 56 or 67 was associated with these biomarkers at 67.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Age 56 MET hours were inversely associated with NfL and GFAP at 67 (NfL: B\u00a0=\u00a0\u22120.10, 95% confidence interval [CI]: \u22120.17 to \u22120.03, GFAP:\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u22120.08, 95% CI: \u22120.15 to \u22120.01) but were not significantly associated with p\u2010tau217 or A\u03b242\/40 ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our NfL and GFAP results suggest that midlife PA may reduce risk for neurodegeneration in older age via amyloid\u2010independent mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71755","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:35:40Z","timestamp":1787204140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective study on physical activity and Alzheimer's disease\u2013related biomarkers"],"prefix":"10.1002","volume":"22","author":[{"given":"Paula","family":"Iso\u2010Markku","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla California USA"},{"name":"Center for Behavior Genetics of Aging University of California  San Diego, La Jolla California USA"},{"name":"Institute for Molecular Medicine Finland (FIMM), HiLIFE University of Helsinki  Helsinki Finland"},{"name":"Clinical Physiology and Nuclear Medicine HUS Diagnostic Center University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin M.","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla California USA"},{"name":"Center for Behavior Genetics of Aging University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Virginia Institute for Psychiatric and Behavior Genetics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Elman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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A.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"},{"name":"Department of Psychology &amp; Neuroscience University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Psychology Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Kremen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San Diego, La Jolla California USA"},{"name":"Center for Behavior Genetics of Aging University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  San 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