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Whether genetic risk for ADHD, estimated using an ADHD polygenic risk score (ADHD\u2010PRS), is associated with incident cognitive impairment (mild cognitive impairment or Alzheimer's disease dementia) remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 7761 cognitively unimpaired (CU) older adults with whole\u2010genome sequencing from eight cohorts participating in the Alzheimer's Disease Sequencing Project (ADSP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up, 1347 participants developed cognitive impairment. Ten\u2010year cumulative incidence was 33.8% in the highest ADHD\u2010PRS tertile versus 23.4% in the lowest. In Cox models, higher ADHD\u2010PRS remained associated with greater risk of cognitive impairment after adjustment for education, apolipoprotein E (\n                      <jats:italic>APOE)<\/jats:italic>\n                      \u03b54 status, or vascular risk. PRSs for other major psychiatric disorders were not associated with cognitive impairment in the same analytic framework. In a subsample with biomarker data, the association was not modified by baseline amyloid\u2010\u03b2 status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings support ADHD\u2010PRS as a novel correlate of cognitive impairment and vulnerability in aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71770","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:00:20Z","timestamp":1792062020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attention\u2010deficit\/hyperactivity disorder polygenic risk score and incidence of cognitive impairment in older adults: A prospective multicohort study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-8451","authenticated-orcid":false,"given":"Douglas Teixeira","family":"Leffa","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Bauer\u2010Negrini","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Bellaver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C. L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Povala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoza Z.","family":"Lussier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Ferrari\u2010Souza","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Hospital Moinhos de Vento  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Tudorascu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Biostatistics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Cortese","sequence":"additional","affiliation":[{"name":"Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences University of Southampton  Southampton UK"},{"name":"Clinical and Experimental Sciences (CNS and Psychiatry) Faculty of Medicine University of Southampton  Southampton UK"},{"name":"Hampshire and Isle of Wight Healthcare NHS Foundation Trust  Southampton UK"},{"name":"New York University Child Study Center, Hassenfeld Children's Hospital at NYU Langone  New York New York USA"},{"name":"DiMePRe\u2010J\u2010Department of Precision and Regenerative Medicine\u2010Ionian Area University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Augusto","family":"Rohde","sequence":"additional","affiliation":[{"name":"ADHD Outpatient Program &amp; Development Psychiatry Program Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Brazil"},{"name":"National Institute of Developmental Psychiatry &amp; National Center for Innovation and Research in Mental Health  S\u00e3o Paulo Brazil"},{"name":"Medical Council UNIFAJ &amp; UNIMAX  Indaiatuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke S. 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