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We screened chemicals for enrichment with dementia genes and related pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We obtained gene lists from Agora and the Comparative Toxicogenomics Database (CTD) for 1008 chemicals and nine dementia\u2010related pathways (e.g., Alzheimer's disease, tauopathies). We tested pairwise chemical\u2013dementia gene enrichment using Fisher exact tests and proportional reporting ratios (PRRs), accounting for multiple comparisons with false discovery rate (FDR\u00a0&lt;\u00a01\u00a0\u00d7\u00a010\n                      <jats:sup>\u22126<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of the chemicals tested, 817 (81.1%) were enriched for at least one dementia pathway and 71 with all nine pathways, including benzo(a)pyrene, ethanol, paraquat, and particulate matter. We observed 295 chemicals enriched for Alzheimer's disease, including sodium arsenite (PRR\u00a0=\u00a057.9) and 305 enriched for tauopathies, including bisphenol A (PRR\u00a0=\u00a037.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We identified chemicals enriched for dementia pathways, suggesting broad classes of chemicals contribute to dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71775","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:43:42Z","timestamp":1787647422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database"],"prefix":"10.1002","volume":"22","author":[{"given":"Scarlet","family":"Cockell","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Patti","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, Genetics and Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin B.","family":"Ware","sequence":"additional","affiliation":[{"name":"Survey Research Center, Institute for Social Research University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.03.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.2\/cqiu"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2022.89236"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz129"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005153\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001024\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010221054"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2001.4254"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5550"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150024"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200282"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010024\u201002718\u20106"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3164"},{"key":"e_1_2_9_18_1","unstructured":"US EPA O.Now Available: Latest Update to the TSCA Inventory. 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