{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:48Z","timestamp":1788671568609,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#82201595"],"award-info":[{"award-number":["#82201595"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neural network and bioenergetic abnormalities occur with Alzheimer's disease (AD) pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We explored mossy fiber (MF) and mitoenergetic alteration using \u0251\u2010smooth muscle actin (\u0251SMA) and cytochrome c oxidase (COX) immunolabeling in human hippocampus relative to tangle and plaque formation by referring to Braak (0\u2013VI) and Thal (0\u20135) staging scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the brain group with Braak\/Thal 0\/0 scores (control), \u0251SMA labeling occurred in CA3 and dentate gyrus. In groups with 1a to IV\/0 and II to VI\/1 to 5 scores, \u0251SMA labeling appeared in CA2 to subiculum, with increased density in these and the dentate subregions. \u0251SMA\u2010labeled MF terminals infiltrated into ghost tangles co\u2010expressing amyloidogenic markers and coexisted among \u03b2\u2010secreatse\u20101 labeled neurites and amyloid beta plaques. COX immunolabeling was increased in CA2 to subiculum in the groups with 1a to IV\/0 to 1 compared to 0\/0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>MF reorganization\/dystrophy develops and integrates with tangle and plaque formation and mitoenergetic alteration in the human hippocampus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71778","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:00:55Z","timestamp":1787382055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant \u0251SMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus"],"prefix":"10.1002","volume":"22","author":[{"given":"Tian","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Hua","family":"Huo","sequence":"additional","affiliation":[{"name":"The Reproductive and Stem Cell Engineering Institute Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchao","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education, Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"The Reproductive and Stem Cell Engineering Institute Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Central South University, Xiangya School of Basic Medical Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507104112"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010019\u20100260\u2010z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010014\u20101349\u20100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010025\u201002862\u2010x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30044\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00959"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24794"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.06.040"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae231"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1397\u201018.2018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02024-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.557416"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2003.11.015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104877"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22105"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430701"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0959\u201006.2006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200835"},{"issue":"3","key":"e_1_2_8_22_1","first-page":"994","article-title":"Screening antiseizure medications to break the cycle between neuronal hyperexcitability and Alzheimer's disease","volume":"107","author":"Barbour AJ","year":"2025","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(25)00425\u20109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251414147"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201000094\u20103"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010026\u201036148\u20103"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70259\u20105"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010018\u20100306\u20107"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100127\u2010z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100910\u20103"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010025\u201000819\u2010y"},{"issue":"3","key":"e_1_2_8_32_1","first-page":"280","article-title":"Brain samples from the central south university Xiangya human brain bank","volume":"57","author":"Zhang QL","year":"2026","journal-title":"Acta Anatomica Sinica"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00093"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201077026\u20100"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b04441"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00859"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(90)90481\u2010N"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.727883"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010023\u201003261\u20107"},{"issue":"5","key":"e_1_2_8_40_1","first-page":"1167","article-title":"Tangle\u2010associated neuritic clusters. A new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with beta\/A4","volume":"140","author":"Munoz DG","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(89)90559\u20104"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20109877(93)90051\u2010Q"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051032"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688880"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691092"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010011\u20109256\u20109"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2009.07017.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2026.03.032"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010199812000\u201000004"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170163"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903560108"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2010.07376.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12676"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109861(19990322)405:4%3c472::AID\u2010CNE3%3e3.0.CO;2\u2010P"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23323"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.003"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010112723\u2010032924"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102001\u20103112"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010007\u20100284\u20108"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12206"},{"issue":"4","key":"e_1_2_8_61_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/brain\/awn256","article-title":"Oskar Fischer and the study of dementia","volume":"132","author":"Goedert M","year":"2009","journal-title":"Brain"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91247-X"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(94)90608\u20104"},{"issue":"2","key":"e_1_2_8_64_1","first-page":"175","article-title":"Stage\u2010correlated distribution of type 1 and 2 dystrophic neurites in cortical and hippocampal plaques in Alzheimer's disease","volume":"39","author":"Thal DR","year":"1998","journal-title":"J Hirnforsch"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14369"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010198803000\u201000006"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010019\u201002108\u20107"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010019\u20100675\u20109"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12546"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201022\u201009785.2002"},{"key":"e_1_2_8_71_1","first-page":"1","volume-title":"Progress in Neuropathology","author":"Wisniewski HM","year":"1973"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003156\u20100"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.03.037"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13133879"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:22:51Z","timestamp":1788668571000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/alz.71778"],"URL":"https:\/\/doi.org\/10.1002\/alz.71778","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71778"}}