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Longitudinally, most p\u2010tau217\u2013positive individuals remained stable (93%\u201398%), whereas the intermediate zone group progressed more to positive (44%\u201378%) than p\u2010tau217\u2013negative individuals (4%\u201321%). Participants with stable\u2010positive and progress\u2010to\u2010positive p\u2010tau217 profiles more frequently exhibited A\u03b2 abnormalities (90%\u2013100% and 64%\u201396%, respectively) and experienced accelerated tau accumulation, hippocampal atrophy, and incident dementia compared to those with a stable\u2010negative p\u2010tau217 profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings support the high stability and A\u03b2\u2010PET classification performance of longitudinal plasma p\u2010tau217 monitoring in AD, providing a scalable tool for risk stratification and disease monitoring.<\/jats:p>\n                  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