{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:51Z","timestamp":1788671571864,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Cerebral amyloid angiopathy (CAA) is a leading cause of lobar intracerebral hemorrhage (ICH) in the elderly. The influence of apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) variants, CAA pathology, and concomitant Alzheimer's disease (AD) neuropathologic changes in determining hemorrhagic risk is incompletely defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 205 autopsy brains with CAA from two Spanish cohorts: a hospital\u2010based series and a cohort of institutionalized patients with dementia. CAA severity was graded using the Vonsattel system and vascular cognitive impairment neuropathology guidelines subscore for CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis identified younger age at death,\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b52 carriage, and vascular remodeling CAA as independent predictors of ICH.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b52 was associated with ICH but not with vascular remodeling. The \u03b52\/\u03b54 genotype showed the highest ICH frequency. Severity of CAA was most strongly associated with ICH in the presence of concomitant AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings support a complex interaction among\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype, vascular amyloid pathology, and concomitant AD changes in shaping the hemorrhagic phenotype of CAA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71786","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:53:23Z","timestamp":1787648003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with intracerebral hemorrhage in confirmed cerebral amyloid 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