{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:51:19Z","timestamp":1791337879986,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201022\u2010969267"],"award-info":[{"award-number":["AARF\u201022\u2010969267"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012513","name":"Coins for Alzheimer's Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072931"],"award-info":[{"award-number":["P30AG072931"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>To optimize a model of amyloid\u2010enhanced tauopathy we compared wild\u2010type (WT) tau with P301L\u2010tau in a mouse with mature amyloid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Mice transgenic for amyloid precursor protein and presenilin\u20101 (APP+PS1, A\/P)\u00a0were injected intravenously with adeno\u2010associated virus with capsid B10 (AAV.CAP\u2010B10) expressing either WT or P301L human tau. Mice were behaviorally assessed 5 and 8 months and tissue collected 9 months after injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A\/P+WT and A\/P+P301L groups were equivalently impaired in spatial learning and memory. A\/P+WT mice had significantly greater tau hyperphosphorylation than A\/P+P301L mice. However, A\/P+P301L mice had greater deposition of phospho\u2010tau and formation of Gallyas\u2010positive neurofibrillary tangles (NFTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These data demonstrate that WT\u2010tau is more highly phosphorylated than P301L\u2010tau in the presence of amyloid in mouse brain. Furthermore, despite the lack of NFT pathology in A\/P+WT mice, WT\u2010tau still caused cognitive impairment. The use of WT\u2010tau in this model may make it more translatable for pre\u2010clinical assessments of potential therapeutics for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71788","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:42:11Z","timestamp":1791294131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A murine model of amyloid\u2010enhanced tauopathy: Comparison of wild\u2010type and P301L\u2010tau"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-9432","authenticated-orcid":false,"given":"Dylan J.","family":"Finneran","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan 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