{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:58Z","timestamp":1788671578405,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Incident microhemorrhages and superficial siderosis are hemorrhagic magnetic resonance imaging (MRI) abnormalities relevant to amyloid\u2010related imaging abnormalities with hemosiderin deposition (ARIA\u2010H) risk stratification, but evidence exploring their short\u2010term dynamic predictors remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed longitudinal MRI data from the A4 study, constructing a discrete person\u2013interval dataset for modeling the short\u2010term risk of incident hemorrhagic MRI abnormalities. Models incorporated baseline covariates, alongside dynamic variables of recent microhemorrhage accumulation and current microhemorrhage burden. The outcome was defined as two or more new microhemorrhages or one or more new superficial siderosis between consecutive MRI scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 1069 participants (3647 intervals), 171 hemorrhagic events occurred. Both current burden (time\u2010to\u2010event: odds ratio [OR] 1.37, 95% confidence interval [CI] 1.09\u20131.73; all\u2010event: OR 1.24, 95% CI: 1.04\u20131.49) and recent microhemorrhage accumulation were independently associated with an increased risk of hemorrhagic events (time\u2010to\u2010event: OR 1.83, 95% CI 1.01\u20133.30; all\u2010event: OR 1.43, 95% CI: 1.00\u20132.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Temporal imaging variables may provide independent prognostic information beyond baseline risk, supporting a dynamic model of hemorrhagic risk in Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Clinical trial of Solanezumab for older individuals who may be at risk for memory loss (A4) (NCT02008357).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71792","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:02:27Z","timestamp":1787821347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic imaging markers of incident microhemorrhages and superficial siderosis in the A4 study: A longitudinal person\u2013interval analysis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4352-1952","authenticated-orcid":false,"given":"Callum","family":"Hill","sequence":"first","affiliation":[{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6936-7014","authenticated-orcid":false,"given":"Huw","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Electronics and Computer Science University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-8388","authenticated-orcid":false,"given":"Sofia","family":"Michopoulou","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton  Southampton UK"},{"name":"Department of Medical Physics University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-140X","authenticated-orcid":false,"given":"Mahesan","family":"Niranjan","sequence":"additional","affiliation":[{"name":"School of Electronics and Computer Science University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-9712","authenticated-orcid":false,"given":"Christopher M.","family":"Kipps","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences Faculty of Medicine University of Southampton  Southampton UK"},{"name":"University Hospital Southampton NHS Foundation Trust  Southampton 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