{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:56Z","timestamp":1788671576740,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neuroinflammatory processes may play a central role in promoting mixed pathologies and cognitive impairment in the oldest\u2010old. We hypothesize that elevated neuroinflammation, indicated by reactive astrocytosis, acts on cerebrovascular disease and separately, on amyloid beta (A\u03b2) pathology, to promote downstream medial temporal lobe atrophy and memory impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined whether plasma glial fibrillary acidic protein (GFAP) concentration is associated with vascular territory\u2010defined white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI), global A\u03b2 burden on positron emission tomography (PET), and episodic memory in a diverse cohort (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a0439) of the oldest\u2010old: The LifeAfter90 Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher plasma GFAP was associated with increased posterior cerebral artery (PCA)\u2010defined WMH volume, but not with global amyloid or episodic memory. Both PCA WMH and global amyloid were associated with lower regional medial temporal lobe cortical thickness, which, in turn, was associated with episodic memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings offer insights into new therapeutic and prevention strategies in the oldest\u2010old population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71795","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:05:13Z","timestamp":1787382313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond amyloid: Contributions of neuroinflammation, cerebrovascular disease, and neurodegeneration to memory impairment in the oldest\u2010old, the LifeAfter90 Study"],"prefix":"10.1002","volume":"22","author":[{"given":"Batool","family":"Rizvi","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Ivan B.","family":"Posis","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary L.","family":"Colbeth","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Vagelos College of Physicians and Surgeons, Columbia University  New York New York USA"},{"name":"Gertrude H. 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