{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:45Z","timestamp":1790334225685,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062528"],"award-info":[{"award-number":["R01AG062528"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Latinos face increased Alzheimer's disease (AD) risk but are underrepresented in studies of\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype disclosure. We evaluated the psychological impacts of\n                      <jats:italic>APOE<\/jats:italic>\n                      disclosure in the Informaci\u00f3n de la Enfermedad de Alzheimer para Latinos (IDEAL) study, a randomized controlled trial among Latinos in New York City.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Latino northern Manhattan residents without self\u2010reported AD (mean age 52, 69% women, 49% college graduates) were randomized in the period August 2021 to July 2024 to receive AD risk estimates to age 85 incorporating\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype, family history, and ethnicity (disclosure) or the same factors excluding\n                      <jats:italic>APOE<\/jats:italic>\n                      (non\u2010disclosure). Bilingual genetic counselors delivered risk estimates to both groups, unmasked to randomization. Follow\u2010up surveys were completed 6\u00a0weeks, 9 months, and 15 months after risk delivery. Primary outcomes were impact of genetic testing in AD (IGT\u2010AD) and Impact of Event Scale\u2010Revised (IES\u2010R). Secondary outcomes were changes from baseline in depression, anxiety, and perceived AD threat. Analyses used intention\u2010to\u2010treat with multiple imputation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Disclosure (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0194) and non\u2010disclosure (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0180) groups did not differ on IGT\u2010AD (mean disclosure\u2212non\u2010disclosure difference [MD] at 6 weeks: \u22121.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.14; 9 months: \u22121.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.35; 15 months: \u22122.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07), IES\u2010R (MD at 6 weeks: 0.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.98; 9 months: 0.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.84; 15 months: 0.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.64), or change in secondary outcomes. Occurrence of disclosure\u2010related adverse events was similar in the disclosure (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a02) and non\u2010disclosure (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a03) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      In this Latino cohort,\n                      <jats:italic>APOE<\/jats:italic>\n                      disclosure did not have clinically significant adverse psychological effects, addressing an important evidence gap.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT04471779.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71796","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:46:29Z","timestamp":1788936389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological impacts of\n                    <i>APOE<\/i>\n                    genotype disclosure among Latinos in New York City: a randomized controlled trial"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-242X","authenticated-orcid":false,"given":"Ruth","family":"Ottman","sequence":"first","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University  New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"},{"name":"Division of Epidemiology, Prevention, and Services Research New York State Psychiatric Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Wetmore","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Shiun","family":"Leu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy R.","family":"Uhlmann","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Internal Medicine and Department of Human Genetics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"},{"name":"Taub Institute, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Diaz Caro","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cab\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Sociomedical Sciences, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McCain","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Health Equity University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Blasco","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Health, School of Public Health University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Lantigua","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vagelos College of Physicians &amp; Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Abraido\u2010Lanza","sequence":"additional","affiliation":[{"name":"Columbia School of Social Work  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Scott","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Health Equity University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolynn","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Sociomedical Sciences, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.056"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200230"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001364\u2010w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.69"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.05.016"},{"key":"e_1_2_8_7_1","first-page":"1627","article-title":"American college of medical genetics\/American society of human genetics working group on ApoE and Alzheimer disease","volume":"274","author":"disease SEA","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340066035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31821d69b8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010016\u20100212\u2010z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanhl.2025.100778"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0300"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.24.2.483"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31815a9dcc"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112002741"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010210675"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2018.13"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180629"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.46"},{"key":"e_1_2_8_22_1","unstructured":"US Census Bureau.Hispanic heritage month: 2023.2023. Accessed October 20 2025.https:\/\/www.census.gov\/newsroom\/facts\u2010for\u2010features\/2023\/hispanic\u2010heritage\u2010month.html"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12589"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1632"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1078"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70016"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13652"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70292"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101497.2001.016009606.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010092010\u2010110722"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318188429e"},{"key":"e_1_2_8_33_1","first-page":"399","volume-title":"Assessing Psychological Trauma and PTSD: A Practitioner's Handbook","author":"Weiss DS","year":"1997"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2003.07.010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093\u2010200301000\u201000003"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.4.800"},{"key":"e_1_2_8_37_1","volume-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin DB","year":"2004"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1021"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000970"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3524"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2010.03.006"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.032"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181cef9e1"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70138"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3599"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12699"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877261435633"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:16:39Z","timestamp":1790331399000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/alz.71796"],"URL":"https:\/\/doi.org\/10.1002\/alz.71796","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71796"}}