{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:42Z","timestamp":1790334222064,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSFD\u201024\u20101310485"],"award-info":[{"award-number":["AACSFD\u201024\u20101310485"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Although Alzheimer's disease (AD) is prevalent in individuals with chronic kidney disease (CKD), the mechanistic link remains unclear. We assessed the impact of CKD transcriptional risk on AD endophenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We calculated the CKD transcriptional risk score (CKD\u2010TRS) using blood transcriptomes from the Alzheimer's Disease Neuroimaging Initiative (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0661) and AddNeuroMerge (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0665) and brain transcriptomes from the Religious Orders Study and Rush Memory and Aging Project (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0622) and analyzed its associations with longitudinal cognition, brain volume, amyloidopathy, tauopathy, and mediation effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher blood\u2010based CKD\u2010TRS was associated with accelerated cognitive decline, rapid temporal cortical atrophy, and faster amyloid accumulation. Brain\u2010based CKD\u2010TRS was similarly linked to faster cognitive decline and greater amyloid burden, with amyloidopathy partially mediating the CKD\u2010TRS\u2013cognition association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest that CKD\u2010TRS is associated with progressive neurodegeneration in AD, mediated by amyloidopathy, highlighting a shared molecular pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71798","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:35:54Z","timestamp":1790303754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional risk score for chronic kidney disease: relation to Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Jung\u2010Min","family":"Pyun","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National 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