{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:03Z","timestamp":1790334183782,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01876"],"award-info":[{"award-number":["2023J01876"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Common Alzheimer's disease (AD) mouse models are widely used, but their molecular correspondence with human AD remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed 15\n                      <jats:italic>post mortem<\/jats:italic>\n                      human brain datasets, four human non\u2010brain or in vitro sensitivity datasets, and nine AD\u2010related mouse\u2010model molecular\u2010profiling datasets; GSE222494 was analyzed separately for single\u2010nucleus localization. Refined107, a meta\u2010refined 107\u2010gene human AD\u2010associated gene subset, was evaluated using recurrence\u2010matched control sampling, independent pathway\u2010level comparison, within cohort out\u2010of\u2010fold (OOF) classification, and ordered cross\u2010cohort transportability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Refined107 comprised 37 Tier 1 and 70 Tier 2 genes and showed greater statistical consistency than recurrence\u2010matched controls. Functional annotation implicated inflammatory, blood\u2013brain barrier, metabolic, neuronal, and developmental programs. Among 636 recurrent human pathways, 226 showed same\u2010direction support in at least one evaluated mouse\u2010model family, indicating partial and model\u2010dependent human\u2013mouse correspondence. Post\u2010selection within\u2010cohort OOF areas under the curve (AUCs) were 0.833 to 0.980, whereas ordered cross\u2010cohort AUCs were 0.288 to 0.720.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Refined107 represents a statistically consistent, meta\u2010refined human AD\u2010associated gene subset rather than a comprehensive disease signature. Human\u2013mouse pathway correspondence was partial and model\u2010dependent, and within\u2010cohort classification did not translate into robust cross\u2010cohort transportability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71804","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:38:21Z","timestamp":1788838701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A meta\u2010refined human Alzheimer's disease\u2010associated gene subset shows partial mouse\u2010model pathway correspondence and limited cross\u2010cohort machine\u2010learning transportability"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8632-9031","authenticated-orcid":false,"given":"Linsong","family":"Chai","sequence":"first","affiliation":[{"name":"College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine  Fuzhou 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