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Cell type\u2013specific molecular features distinguishing LATE\u2010NC\u2010dominant, ADNC\u2010dominant, and mixed LATE\u2010NC and ADNC pathology remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed single\u2010nucleus RNA sequencing data from the Seattle Alzheimer's Disease Brain Cell Atlas consortium, focusing on non\u2010neuronal cells in the middle temporal gyrus (MTG). Donors were stratified into LATE\u2010NC dominant, ADNC dominant, and mixed LATE\u2010NC and ADNC. Differential expression and gene set enrichment analyses were performed across glial and vascular cell supertypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Distinct transcriptional patterns differentiated pathologies. Astrocytes, microglia, and oligodendrocytes exhibited differential expression between LATE\u2010NC\u2010 and ADNC\u2010dominant cases. Representative genes and pathways highlighted these distinctions, with LATE\u2010NC dominant showing enrichment in signaling and RNA regulation, ADNC dominant in mitochondrial dysfunction, and mixed pathology in translational dysregulation and lipid remodeling, suggesting a distinct biological state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings highlight biological heterogeneity and non\u2010neuronal molecular features relevant to disease classification and future research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION INFORMATION<\/jats:title>\n                    <jats:p>Not applicable. This study is a secondary analysis of publicly available Seattle Alzheimer's Disease Brain Cell Atlas (SEA\u2010AD) data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71810","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:07:11Z","timestamp":1790226431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct single\u2010nucleus RNA\u2010seq changes among non\u2010neuronal cells in ADNC, LATE\u2010NC, and mixed pathologies"],"prefix":"10.1002","volume":"22","author":[{"given":"Qi","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Biostatistics College of Public Health University of Kentucky  Lexington Kentucky USA"},{"name":"Sanders\u2010Brown Center on Aging and Alzheimer's Disease Research Center University of Kentucky  Lexington Kentucky 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