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Age\/sex\u2010adjusted models assessed diagnostic and sex effects, associations with plasma biomarkers and Mini\u2010Mental State Examination (MMSE), and mediation of the hippocampal volume\u2013cognition relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>QTM velocity was reduced already in SCD, including the hippocampus, whereas CBF declined mainly in MCI\/AD. Sex \u00d7 Diagnosis interactions were significant for QTM in gray and white matter, but not for CBF. QTM, especially in females, was inversely associated with plasma NfL\/GFAP, related to MMSE, and parietal QTM partially mediated the hippocampal volume\u2013MMSE association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>QTM is a non\u2010invasive biomarker more sensitive than CBF to early, female\u2010biased microvascular transport dysfunction in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71811","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:06:56Z","timestamp":1788232016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease 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