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A treatment scenario slowed the rate of clinical progression by 29% over individuals\u2019 remaining lifetime (baseline mean age: 73.0); earlier treatment initiated 2 years earlier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Treatment generated $104,885 (95% CI: $99,291, $110,479) in gross societal value over an individual's lifetime, including quality\u2010of\u2010life gains, reduced caregiving burden, and medical cost offsets driven by reduced nursing home use and Medicaid spending. Earlier treatment increased value 32%; this rose to 71% if treatment effects are also stronger (36% slowing) in earlier AD stages. Scenarios with 4\u2010year effect duration yielded $49,122 (treatment) and $56,385 (earlier treatment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Timely treatment consistently increased long\u2010term societal value. The findings provide a benchmark against which treatment implementation costs can be weighed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71819","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:00:37Z","timestamp":1791370837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The value of timely treatment with anti\u2010amyloid therapy for Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-9449","authenticated-orcid":false,"given":"Jack M.","family":"Chapel","sequence":"first","affiliation":[{"name":"Sol Price School of Public Policy University of Southern California  Los Angeles California USA"},{"name":"Leonard D. 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Schaeffer Institute for Public Policy and Government Service University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Goldman","sequence":"additional","affiliation":[{"name":"Sol Price School of Public Policy University of Southern California  Los Angeles California USA"},{"name":"Leonard D. Schaeffer Institute for Public Policy and Government Service University of Southern California  Los Angeles California USA"},{"name":"Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Aisen","sequence":"additional","affiliation":[{"name":"Leonard D. Schaeffer Institute for Public Policy and Government Service University of Southern California  Los Angeles California USA"},{"name":"Alzheimer's Therapeutic Research Institute University of Southern California  San Diego California USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71480"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70151"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100446"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70905"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(23)00193\u20109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.1749"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/haschl\/qxae088"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12470"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70094"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70162"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.70129"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18078"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170078"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010011146"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.04.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001577"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010018\u20104377\u2010y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71577"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71549"},{"key":"e_1_2_10_25_1","unstructured":"Future Elderly Model. 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