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We identified 22 shared loci, including novel associations implicating\n                      <jats:italic>GAK<\/jats:italic>\n                      and\n                      <jats:italic>SIAH3<\/jats:italic>\n                      , with the strongest convergence at 17q21.31. Shared loci mapped to 183 protein\u2010coding genes enriched in the endolysosomal system and microtubule cytoskeleton. These genes showed similar temporal expression patterns, and 45 were associated with both DTI\u2010ALPS traits and NDDs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings reveal a shared genetic architecture between DTI\u2010ALPS traits and NDDs, highlighting mechanisms that may contribute to their overlap.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71820","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:49:19Z","timestamp":1788936559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared genetic architecture between DTI\u2010ALPS traits and neurodegenerative diseases"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-3420","authenticated-orcid":false,"given":"Hong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy of Hunan Province The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang China"},{"name":"Hunan Provincial Key Laboratory of Multi\u2010omics and Artificial Intelligence of Cardiovascular Diseases University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital Hengyang Medical School University of South China  Hengyang 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