{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:35Z","timestamp":1790334215084,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SAGA23\u20101140910"],"award-info":[{"award-number":["SAGA23\u20101140910"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Postmenopausal estrogen decline may contribute to Alzheimer's disease (AD), but evidence linking circulating estrogens to cerebrospinal fluid (CSF) AD biomarkers remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed 854 female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study with baseline serum estradiol and estrone measured by liquid chromatography\u2013tandem mass spectrometry and repeated CSF amyloid\u2010beta 42 (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ), phosphorylated tau 181 (pTau\n                      <jats:sub>181<\/jats:sub>\n                      ), and total tau (tTau). Models used regression for cross\u2010sectional analyses and mixed\u2010effects models restricted to the 187 participants with follow\u2010up, adjusted for age, body mass index, waist circumference, and hormone replacement therapy (HRT) use. We also tested apolipoprotein E\n                      <jats:italic>\u03b54<\/jats:italic>\n                      (\n                      <jats:italic>APOE\u03b54<\/jats:italic>\n                      ) and amyloid moderation and conducted sensitivity analyses excluding current HRT users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Neither hormone was associated with A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      . Higher estradiol was associated with lower baseline tau, especially among\n                      <jats:italic>APOE\u03b54<\/jats:italic>\n                      carriers, but not with tau change. In exploratory longitudinal analyses, estrone showed a modest association with slower pTau\n                      <jats:sub>181<\/jats:sub>\n                      increase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Findings suggest more consistent cross\u2010sectional associations of estradiol with tau than with A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ; longitudinal findings were limited by attrition and should be interpreted as exploratory.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71826","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:53:04Z","timestamp":1789354384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between serum estradiol and estrone and Alzheimer's disease biomarkers: An analysis in female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS)"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-794X","authenticated-orcid":false,"given":"Juehyun","family":"Shin","sequence":"first","affiliation":[{"name":"Heritage College of Osteopathic Medicine Ohio University  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Muniz\u2010Terrera","sequence":"additional","affiliation":[{"name":"Heritage College of Osteopathic Medicine Ohio University  Athens Ohio USA"},{"name":"The Alzheimer's Pathobiome Initiative (AlzPI)  Wake Forest North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Scottish Brain Sciences  Edinburgh UK"},{"name":"University of St Andrews  St Andrews UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Manson","sequence":"additional","affiliation":[{"name":"University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Plachecki","sequence":"additional","affiliation":[{"name":"Dresden LABservice GmbH  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Kirschbaum","sequence":"additional","affiliation":[{"name":"Dresden LABservice GmbH  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gregory","sequence":"additional","affiliation":[{"name":"Scottish Brain Sciences  Edinburgh UK"},{"name":"University of St Andrews  St Andrews UK"},{"name":"University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Global status report on the public health response to dementia. 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