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Moreover, a higher MARBLE score was associated with higher LATE\u2010NC stages (\u03b2\u00a0=\u00a00.083, 95% confidence interval\u00a0=\u00a0[0.053, 0.113],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a010\n                      <jats:sup>\u22124<\/jats:sup>\n                      ), and a lower level and accelerated decline of cognition, with the strongest effects observed in episodic and semantic memory, and perceptual speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a010\n                      <jats:sup>\u22124<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>MARBLE is an automated in vivo MRI\u2010based marker of LATE\u2010NC holding significant promise for enhancing diagnosis, refining clinical trial enrollment, and advancing targeted therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71832","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:56:46Z","timestamp":1789531006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MARBLE: An in vivo MRI marker of limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathologic change (LATE\u2010NC)"],"prefix":"10.1002","volume":"22","author":[{"given":"Mahir","family":"Tazwar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Illinois Institute of Technology  Chicago Illinois USA"},{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold M.","family":"Evia","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University 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