{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:02:45Z","timestamp":1790334165899,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302081"],"award-info":[{"award-number":["82302081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The role of complement in Alzheimer's disease (AD) remains unclear, particularly regarding tau pathology and memory decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In 123 mild cognitive impairment (MCI) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI), linear mixed\u2011effects models and Johnson\u2013Neyman analysis examined associations of baseline cerebrospinal fluid (CSF) C3\/FH ratio with longitudinal memory decline moderated by time\u2011varying plasma phosphorylated tau181 (p\u2011tau181).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The three\u2011way interaction was significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023). A region of statistical significance was identified: the conditional association of C3\/FH with memory decline became significant when p\u2011tau181 exceeded 0.76 SD, with higher C3\/FH associated with slower decline at elevated p\u2011tau181 levels. Cross\u2010sectionally, no significant C3\/FH\u2013memory associations were observed in any diagnostic group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings indicate that complement balance is associated with memory decline in MCI in a manner dependent on plasma p\u2011tau181 levels, suggesting that complement may interact with AD\u2011related pathophysiology during the prodromal phase. The identified statistical region provides a hypothesis\u2011generating benchmark for future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71836","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:10:29Z","timestamp":1789963829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p\u2011tau181 levels in mild cognitive impairment"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhinan","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine Taizhou University  Taizhou Zhejiang 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