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Individuals were classified as WMH\u2010only or WMH+ (WMHs with microbleeds, infarcts, or cerebral amyloid angiopathy). Linear models tested interactions between sleep duration, WMH+ status, and diagnostic group on WMH burden and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In MCI+V and AD, WMH+ significantly amplified the association between shorter sleep and greater WMH burden. In AD, longer sleep related to better cognition in WMH+ but worse cognition in WMH\u2010only (exploratory).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Additional vascular brain injury modifies how sleep relates to WMH burden and cognition across the AD continuum, highlighting the importance of moving beyond WMHs alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71838","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:27:19Z","timestamp":1791800839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vascular brain injury modifies the relationship between sleep duration, cognition, and white matter hyperintensity burden in the Alzheimer's disease continuum"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-8212","authenticated-orcid":false,"given":"Soraya","family":"Lahlou","sequence":"first","affiliation":[{"name":"Multiomics Investigation of Neurodegenerative Diseases (MIND) Laboratory  Montr\u00e9al Quebec Canada"},{"name":"Centre de Recherche de l'Institut Universitaire de G\u00e9riatrie de Montr\u00e9al (CRIUGM)  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien Thanh","family":"Dang\u2010Vu","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l'Institut Universitaire de G\u00e9riatrie de Montr\u00e9al (CRIUGM)  Montr\u00e9al Quebec Canada"},{"name":"Sleep, Cognition and Neuroimaging Laboratory, Department of Health, Kinesiology and Applied Physiology Concordia University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AmanPreet","family":"Badhwar","sequence":"additional","affiliation":[{"name":"Multiomics Investigation of Neurodegenerative Diseases (MIND) Laboratory  Montr\u00e9al Quebec Canada"},{"name":"Centre de Recherche de l'Institut Universitaire de G\u00e9riatrie de Montr\u00e9al (CRIUGM)  Montr\u00e9al Quebec Canada"},{"name":"D\u00e9partement de pharmacologie et physiologie, Facult\u00e9 de m\u00e9decine Universit\u00e9 de Montr\u00e9al  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