{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:37Z","timestamp":1791295477896,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG062217"],"award-info":[{"award-number":["R01 AG062217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG051500"],"award-info":[{"award-number":["R01 AG051500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG055072"],"award-info":[{"award-number":["R01 AG055072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072931"],"award-info":[{"award-number":["P30 AG072931"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201022\u2010969267"],"award-info":[{"award-number":["AARF\u201022\u2010969267"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Our prior work demonstrated systemic P301L\u2010tau injections in mice with mature amyloid resulted in several\u2010fold enhancement of tauopathy compared to non\u2010transgenic (NTg) littermates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>APP+PS1 mice were injected intravenously with AAV.CAP\u2010B10 expressing P301L tau (A\/P+P301L). Mice were tested behaviorally and tissues collected for measurement of amyloid and tau pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A\/P+P301L mice have greater spatial navigation memory impairments than control APP+PS1 mice, or AAV\u2010tau injected NTg mice. Tau phosphorylation and deposition increased from 5 to 9 months after injection, culminating in numerous Gallyas\u2010positive presumptive neurofibrillary tangles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In this model of amyloid\u2010enhanced tauopathy, tau pathology acts synergistically with amyloidosis to exacerbate cognitive impairments compared to amyloid\u2010only mice. The tauopathy is progressive, with more severe behavioral impairments and neurofibrillary deposits at longer survival times. The temporal staging of pathology in this model resembles that of Alzheimer's disease and may be useful for interrogating the linkage between amyloid and tau pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71839","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:49:52Z","timestamp":1791294592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-9432","authenticated-orcid":false,"given":"Dylan J.","family":"Finneran","sequence":"first","affiliation":[{"name":"Dept of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Desjarlais","sequence":"additional","affiliation":[{"name":"Dept of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna M.","family":"Jackman","sequence":"additional","affiliation":[{"name":"Dept of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-7476","authenticated-orcid":false,"given":"David","family":"Morgan","sequence":"additional","affiliation":[{"name":"Dept of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia N.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Dept of Translational Neuroscience College of Human Medicine Michigan State University  Grand Rapids Michigan 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through synergistic interactions among amyloid\u2010beta, tau, and reactive astrogliosis","volume":"46","author":"Han YE","year":"2025","journal-title":"Zool 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