{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:48:28Z","timestamp":1792129708364,"version":"4.4.0"},"reference-count":286,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5R01AG070866"],"award-info":[{"award-number":["5R01AG070866"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature and their thermoregulatory function. This review evaluates a framework for pathophysiological interactions between thermoregulation and AD anchored in the functional anatomy of thermoregulatory neurons. Findings in humans show that thermoregulatory neurons exhibit tau pathology in early AD, and abnormal Tb rhythm is seen in advanced AD. In rodents, cellular risk pathways for tau aggregation are both modulated by diurnal range temperature change and involved in thermoregulation. Further research is needed to bridge human and rodent findings, to understand how sex differences in Tb impact AD risk, and to identify modifiable causal links between Tb disturbance and pathophysiology toward improving clinical outcomes in early AD.<\/jats:p>","DOI":"10.1002\/alz.71847","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:20:33Z","timestamp":1792128033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Esther","family":"Blessing","sequence":"first","affiliation":[{"name":"Department of Psychiatry NYU Grossman School of Medicine  New York New York USA"},{"name":"Neuroscience Institute NYU Grossman School of Medicine  New York New York USA"},{"name":"Nathan Kline Institute for Psychiatric Research  Orangeburg New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12937"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160606100509"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12387"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12289"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201097\u20104584\u20105_10"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2887\u201019.2020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009056\u20101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2020.1743605"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.4.353"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756\u2010199504190\u201000022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab466"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.09.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.1991.tb02904.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.09.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1568\u20101637(02)00030\u20102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00202.2003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609814666210624121603"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333148"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00528"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.13.5.359"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.5.704"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20104580(95)00059\u2010n"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.04.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/002383099200500202"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212774"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(96)00167\u20104"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095386"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn049"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010020518\u2010114546"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.02.022"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/b978\u20100\u2010444\u201063912\u20107.00001\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.70002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010009\u20101295\u2010z"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19074"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2027"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201005327\u20108"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.210047"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add5463"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.03.039"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00808.2004"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104522(01)00251\u20102"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012989"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010021\u201000532\u2010x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3752\u201006.2006"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040504\u20106"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.152686"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00094.2015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3223\u201010.2011"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9414"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.028"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.05.054"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0213\u201016.2016"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020050\u20101"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102108"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2021.1993734"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.665762"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201006590\u20107"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7537"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.11.008"},{"issue":"5","key":"e_1_2_10_62_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtherbio.2009.02.002","article-title":"Quantifying the instability of core temperature in rodents","volume":"34","author":"Gordon C","year":"2009","journal-title":"J Therm Biol"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000320"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756\u2010199812210\u201000028"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(87)90325\u20109"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.35.8.1089"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu222"},{"issue":"1","key":"e_1_2_10_68_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.084555","article-title":"The VLPO analog in the human hypothalamus shows tau\u2010driven extreme loss of sleep\u2010regulating neurons in PSP and Alzheimer's disease: unveiling the basis of NREM sleep dysfunction in tauopathies","volume":"20","author":"Rastegar\u2010Pouyani S","year":"2024","journal-title":"Alzheimers Dement"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0305\u20101846.2000.00291.x"},{"key":"e_1_2_10_70_1","volume-title":"Atlas of the Human Brain","author":"Mai JK","year":"2016"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0587\u201022.2022"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.024"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.01.008"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010173"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2019.11.008"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00336"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873049200700407"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62073"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201021175\u20103"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43400"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.236497"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)91506\u20107"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0170"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(02)03808\u20108"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(00)02561\u20100"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.035"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(09)90019\u20101"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8446900"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00890.2009"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(01)02355\u20101"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4284\u201006.2007"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00047.2022"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277664"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc\u20102011\u20100066"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.11.017"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010002\u20100322\u2010x"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1458437"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112849"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0378\u20100.2010"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029134"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13204"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)90218\u20106"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2422878122"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23062905"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18\u201012\u201004705.1998"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)01299\u2010w"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002456"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1735"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7754"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20103057(91)90317\u2010u"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00660"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14726"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad077.0095"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/43366"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102869.2008.00713.x"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaf090.0049"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.02.004"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010019\u20100478\u20105"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101541"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.06.583765"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.3916"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105748"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010012\u20100864\u20101"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0049"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh129"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.08.017"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae078"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz266"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI182931"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.06.052"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069609"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20970"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010018\u20100026\u2010z"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.13\u201003\u201001065.1993"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00093.2005"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.28.620609"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21\u201013\u201004864.2001"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23812"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201033\u201010691.2003"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010002\u20100043\u20109"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545854"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.030"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2337\u201021.2022"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010022\u201001252\u20101"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.150"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010532\u20102"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.319228.118"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195027"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.12.001"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1449\u201015.2015"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0351\u201024.2024"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195262"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316646121"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19\u201019\u201008630.1999"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050034"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183251.111"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.453808"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217726"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201002473\u2010x"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.006"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202217157"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051369"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.23670"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16431"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010021909\u2010135821"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2015.80.027490"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010016\u20102253\u20107"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(02)01145\u20104"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700216"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.01.028"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666\u20107568(20)30015\u20105"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4968"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000695\u20104"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.088431"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(85)91350\u20102"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010199901000\u201000004"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040546\u2010w"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3843"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1379\/1466\u20101268(2000)005<0471:fathsr>2.0.co;2"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13060485"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001757\u20109"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08596"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00709.2007"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26088"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(95)02036\u20105"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2004.03469.x"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2007.05796.x"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2576"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.04.001"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.11.009"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.015"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005\u2010014\u20100286\u2010x"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10010065"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803609115"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.910738"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3009"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00346.2009"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9841"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209412200"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010020\u201000583\u20100"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010011\u20109639\u2010z"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.18.3.673\u2010679.1977"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0511229"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1049782"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012894118"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010012\u20102591\u20103"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010023\u201004075\u20108"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115184"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2007.06.002"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3186509"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.11.016"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576\u2010024\u201000948\u2010x"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)70016\u20105"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010014\u20108657\u20101"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7611"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.012"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.53.7.1495"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf026"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13209"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14040243"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010023\u201000776\u20109"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.93"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.019"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114193109"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519949"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19970115"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.02.007"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14353"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.03.028"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007527"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5561\u201003.2004"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.179812"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.016"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101462"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20786"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529609037076"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141448"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002439\u2010w"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2021.100391"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.006"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1038\/469476a"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010012\u20100320\u2010z"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1587"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.03.054"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441947"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00254"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2006.05250.x"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00117.2013"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014530"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4854\u201006.2007"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46359"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.10.004"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.09.024"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013845"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13723"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2003.08.006"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.004"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12277"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201016626\u20100"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300560"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.24.609514"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102011\u2010110725"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018115\u20102"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa179"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf255"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015217108"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ady2822"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050166\u20107"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5741\u201009.2010"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010017\u20101466\u20103"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01061"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000626\u2010y"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0429"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3599"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.1470"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw212"},{"key":"e_1_2_10_282_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.587397"},{"key":"e_1_2_10_283_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00350"},{"key":"e_1_2_10_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.006"},{"key":"e_1_2_10_285_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0321117"},{"key":"e_1_2_10_286_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2020.1735927"},{"key":"e_1_2_10_287_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201003084\u20107"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:20:37Z","timestamp":1792128037000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":286,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/alz.71847"],"URL":"https:\/\/doi.org\/10.1002\/alz.71847","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71847"}}