{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:19Z","timestamp":1790334199873,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In semantic dementia (SD), no consistent prognostic factors for early care home (CH) admission or mortality have been identified, despite their potential utility in care management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Over a 31\u2010year period, we collected sociodemographic, neuroimaging, neuropsychological, and behavioral data within a large cohort of 90 SD patients. Survival and risk factor analyses were conducted to identify variables mostly influencing CH admission and\/or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Half of the patients were admitted to CH 7.5 years after diagnosis, and half died after 8.4 years. Behavior emerged as the sole baseline prognostic factor and even mild behavioral disorders were\u00a0linked to earlier CH admission (3.0 years) and shorter survival (3.6 years), without influence of the predominant side of anterior temporal atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Behavioral disorders are a major risk factor for loss of independence in SD and a usable prognostic marker in clinical practice, regardless of the predominant side of temporal atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71859","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:37:56Z","timestamp":1790059076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behavior determines times to care home admission and death in semantic dementia: Insights from a cohort of 90 cases"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-7308","authenticated-orcid":false,"given":"Marc","family":"Melkonian","sequence":"first","affiliation":[{"name":"Memory and Resource Center (CMRR), Neurology Department Rennes University Hospital  Rennes Brittany France"},{"name":"Inserm, U1077, EPHE, Neuropsychologie et imagerie de la m\u00e9moire humaine, UNICAEN PSL Research University, Normandie universit\u00e9, CHU de Caen, Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lucas","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Bretagne Atlantique, Vannes Cedex  Vannes Brittany France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Merck","sequence":"additional","affiliation":[{"name":"Memory and Resource Center (CMRR), Neurology Department Rennes University Hospital  Rennes Brittany France"},{"name":"Inserm, U1077, EPHE, Neuropsychologie et imagerie de la m\u00e9moire humaine, UNICAEN PSL Research University, Normandie universit\u00e9, CHU de Caen, Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Salmon","sequence":"additional","affiliation":[{"name":"Memory and Resource Center (CMRR), Neurology Department Rennes University Hospital  Rennes Brittany France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Eustache","sequence":"additional","affiliation":[{"name":"Inserm, U1077, EPHE, Neuropsychologie et imagerie de la m\u00e9moire humaine, UNICAEN PSL Research University, Normandie universit\u00e9, CHU de Caen, Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Laisney","sequence":"additional","affiliation":[{"name":"Inserm, U1077, EPHE, Neuropsychologie et imagerie de la m\u00e9moire humaine, UNICAEN PSL Research University, Normandie universit\u00e9, CHU de Caen, Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Belliard","sequence":"additional","affiliation":[{"name":"Memory and Resource Center (CMRR), Neurology Department Rennes University Hospital  Rennes Brittany France"},{"name":"Inserm, U1077, EPHE, Neuropsychologie et imagerie de la m\u00e9moire humaine, UNICAEN PSL Research University, Normandie universit\u00e9, CHU de Caen, Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14640747508400525"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/1989\/124043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.6.1783"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2013.07.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2010.07.2419"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac217"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa225"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14076"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.3307"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp248"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17582024.2025.2527553"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002638"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11091113"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342347"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15557"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010024\u201012430\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209793"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14558"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2013.776523"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010324903"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010324349"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001146\u2010w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010021\u201002378\u20100"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.51.6.1546"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.216"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010009\u20100521\u2010z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","unstructured":"RavenJC Manual for Raven's progressive matrices and vocabulary scales. Standard Progressive Matrices1983.","DOI":"10.1007\/978-1-4899-2151-2_8"},{"key":"e_1_2_8_33_1","volume-title":"The assessment of aphasia and related disorders","author":"Goodglass H","year":"1972"},{"key":"e_1_2_8_34_1","first-page":"26","article-title":"Une (petite) batterie d\u2019\u00e9valuation de l'orthographe","volume":"67","author":"Croisile B","year":"1999","journal-title":"Glossa"},{"key":"e_1_2_8_35_1","volume-title":"Contributions to neuropsychological assessment: A clinical manual","author":"Benton AL","year":"1983"},{"key":"e_1_2_8_36_1","first-page":"206","article-title":"Le test de copie d'une figure complexe; contribution a l'etude de la perception et de la memoire","volume":"30","author":"Osterrieth PA","year":"1944","journal-title":"Arch Psychol (Geneve)"},{"key":"e_1_2_8_37_1","unstructured":"Protocole Montr\u00e9al\u2010Toulouse \u00c9valuation des gnosies visuelles et auditives. Isbergues (Pas\u2010de\u2010Calais):L'Ortho \u00e9d.;1992."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1684\/nrp.2011.0194"},{"key":"e_1_2_8_39_1","unstructured":"DelocheG HannequinD Test de d\u00e9nomination orale d'images\u00a0: DO 80. Test de D\u00e9nomination Orale d'images\u00a0: DO 80 \/de G Deloche et D Hannequin1997."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.01.003"},{"key":"e_1_2_8_41_1","first-page":"10","article-title":"Pr\u00e9sentation d'une batterie fran\u00e7aise de personnes c\u00e9l\u00e8bres. R\u00e9sultats aupr\u00e8s de patients atteints de d\u00e9mence s\u00e9mantique","volume":"157","author":"Belliard S","year":"2001","journal-title":"Rev Neurol"},{"key":"e_1_2_8_42_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing. Vienna Austria: R Foundation for Statistical Computing;2025."},{"key":"e_1_2_8_43_1","unstructured":"TherneauTM.A Package for Survival Analysis in R.2024."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_8_45_1","unstructured":"KassambaraA KosinskiM BiecekP survminerDrawing Survival Curves using \u201cggplot2.\u201d2025."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20104356(96)00236\u20103"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13887"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000539335"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170657"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.05.014"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.05.014"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158425.46019.5C"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2024.09.002"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010021\u201010689\u20101"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp037"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv387"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurop.2024.100175"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.53.5.471"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000264"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100021053"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.44.12.2308"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40473\u2010020\u201000224\u20103"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab410"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71859","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:15:02Z","timestamp":1790331302000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/alz.71859"],"URL":"https:\/\/doi.org\/10.1002\/alz.71859","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71859"}}