{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:43Z","timestamp":1790650843377,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG073267"],"award-info":[{"award-number":["R01AG073267"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["34874"],"award-info":[{"award-number":["34874"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","award":["33397"],"award-info":[{"award-number":["33397"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010805","name":"Fundaci\u00f3n Tatiana P\u00e9rez de Guzm\u00e1n el Bueno","doi-asserted-by":"publisher","award":["IIBSP\u2010DOW\u20102020\u2010151"],"award-info":[{"award-number":["IIBSP\u2010DOW\u20102020\u2010151"]}],"id":[{"id":"10.13039\/501100010805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010552","name":"Departament de Salut, Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","award":["#0000000158"],"award-info":[{"award-number":["#0000000158"]}],"id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.218211\/2025\u201001"],"award-info":[{"award-number":["88881.218211\/2025\u201001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We compared the association between mild behavioral impairment (MBI) and first\u2010 versus second\u2010generation tau\u2010positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We assessed 110 individuals with head\u2010to\u2010head [\n                      <jats:sup>18<\/jats:sup>\n                      F]MK6240 and [\n                      <jats:sup>18<\/jats:sup>\n                      F]Flortaucipir tau\u2010PET. Voxel\u2010wise and region\u2010of\u2010interest analyses investigated relationships between tau\u2010PET and MBI Checklist (MBI\u2010C) scores, which were also compared across tau\u2010PET positivity and PET\u2010Braak stages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      For both tracers, MBI severity was associated with tau\u2010PET signal in all Braak regions and increased across PET\u2010Braak stages. [\n                      <jats:sup>18<\/jats:sup>\n                      F]MK6240 showed more extensive voxel\u2010wise associations with MBI\u2010C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [\n                      <jats:sup>18<\/jats:sup>\n                      F]MK6240 but negative for [\n                      <jats:sup>18<\/jats:sup>\n                      F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      MBI in early AD is associated with tau\u2010PET, with [\n                      <jats:sup>18<\/jats:sup>\n                      F]MK6240 providing greater sensitivity to detect MBI\u2010related symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71861","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:51:20Z","timestamp":1790650280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tau\u2010PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head\u2010to\u2010head comparison of Flortaucipir and MK6240"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-425X","authenticated-orcid":false,"given":"Isabella","family":"Bizzi","sequence":"first","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Oral Pathology Research Center S\u00e3o Leopoldo Mandic Institute  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-0284","authenticated-orcid":false,"given":"Arthur C.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Trudel","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoza Z.","family":"Lussier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tissot","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Lawrence Berkeley National Laboratory  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Bezgin","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9tienne","family":"Aumont","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevy","family":"Chan","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Geriatric Medicine Department of Medicine McGill University  Montreal Qu\u00e9bec Canada"},{"name":"The Research Institute of the McGill University Health Centre  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Oliva\u2010Lopez","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Pereira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Povala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C. L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Bellaver","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ruppert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Scop","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan","family":"Mrou\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Pin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neuroscience Institute Singapore Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo R.","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Brain Institute of Rio Grande do Sul PUCRS  Porto Alegre Brazil"},{"name":"Graduate Program in Biological Sciences: Pharmacology and Therapeutics; and Biochemistry Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Neuroscience Unit Hospital Moinhos de Vento  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Masdeu","sequence":"additional","affiliation":[{"name":"Department of Neurology Houston Methodist Research Institute and Weill Cornell Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Neurology Houston Methodist Research Institute and Weill Cornell Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwamee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Soleimani\u2010Meigooni","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory  Berkeley California USA"},{"name":"Edward and Pearl Fein Memory and Aging Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, IR SANT PAU Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Barcelona Down Medical Center Fundaci\u00f3 Catalana S\u00edndrome de Down  Barcelona Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Cumming School of Medicine Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"O'Brien Institute for Public Health Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Baker","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick A","family":"Pascoal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurology School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa\u2010Neto","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory Montreal Neurological Institute, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC) McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Douglas Hospital Research Centre, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et services sociaux de l'Ouest\u2010de\u2010l\u2019\u00cele\u2010de\u2010Montr\u00e9al  Verdun Quebec Canada"},{"name":"Montreal Neurological Institute McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"The Peter O'Donnell Jr. Brain Institute (OBI) University of Texas Southwestern Medical Centre (UTSW) Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the HEAD Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6153"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000631\u20106"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12519"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2024.136"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf156"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/08919887251366634"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70119"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001206\u2010z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2024.02.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2024.09.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171678"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101740\u20108"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264434"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267539"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(26)00417\u20104"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052265\u2010x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00340"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000587\u20105"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000223"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14162"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.245209"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae043"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa180"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2025.11.002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00171"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100127\u2010z"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.265200"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010026\u201007886\u20103"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105080"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010026\u201000945\u20101"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010026\u201001143\u2010w"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160979"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218000698"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180131"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597\u2010020\u20100557\u20109"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121945"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0676"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70153"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12154"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14229"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010026\u201001980\u20102"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2025.09.003"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001675\u20102"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12483"},{"issue":"8","key":"e_1_2_8_54_1","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and tau with cognition in preclinical Alzheimer disease: a longitudinal study","volume":"76","author":"Hanseeuw BJ","year":"2019","journal-title":"JAMA Neurol"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003400\u20107"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.45175"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010181285"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251328712"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010021\u201005401\u20104"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002672\u2010z"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267539"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.15"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230898"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad098"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002049\u2010x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2026.106460"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010024\u201006603\u20102"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220\u2010023\u201000043\u2010x"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610224000590"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahr.2024.100207"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:51:24Z","timestamp":1790650284000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/alz.71861"],"URL":"https:\/\/doi.org\/10.1002\/alz.71861","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71861"}}