{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:03:42Z","timestamp":1790334222858,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016101","name":"Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Conventional cognitive instruments exhibit limited efficacy in detecting insidious cognitive decline in subjective cognitive decline (SCD) due to neural compensation. We hypothesized that auditory distraction during a visual memory task would unmask preclinical amyloid beta (A\u03b2) vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We evaluated 112 participants (SCD and mild cognitive impairment [MCI]) using the MemTrax test under quiet and noisy conditions to quantify distraction costs (d\u2010MTxc). A\u03b2 status and cognitive reserve were assessed via positron emission tomography and the Cognitive Reserve Index questionnaire (CRIq).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A\u03b2\u2010positive SCD individuals performed normally in quiet but showed higher d\u2010MTxc than A\u03b2\u2010negative peers (11.17\u00a0\u00b1\u00a05.762\u00a0vs 6.67\u00a0\u00b1\u00a05.096). Higher CRIq\u2010WorkingActivity (CRIW) scores identified A\u03b2 positivity and moderated performance. The combination of d\u2010MTxc and CRIW accurately classified A\u03b2 positivity (AUC\u00a0=\u00a00.836), whereas MCI individuals exhibited metabolic network fragmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Auditory distraction taxes cognitive capacity to expose compensatory failures coupled with A\u03b2 burden. This paradigm, interacting with occupational reserve, offers a promising digital biomarker framework for preclinical Alzheimer's screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71874","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:41:31Z","timestamp":1790059291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking preclinical Alzheimer's pathology: auditory distraction cost and occupational reserve jointly discriminate amyloid positivity in subjective cognitive decline"],"prefix":"10.1002","volume":"22","author":[{"given":"Yating","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weineng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Hartford  West Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O. Clifford","family":"Jr","sequence":"additional","affiliation":[{"name":"Department of Psychology College of San Mateo  San Mateo California USA"},{"name":"War Related Illness and Injury Study Center (WRIISC) VA Palo Alto Health Care System  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Wesson","family":"Ashford","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences Stanford University  Palo Alto California USA"},{"name":"War Related Illness &amp; Injury Study Center VA Palo Alto Health Care System  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's Research Washington Institute of Clinical Research  Vienna Virginia USA"},{"name":"AstraNeura, Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongliang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shenzhen People's Hospital (The First Affliated Hospital Southern University of Science and Technology)  Shenzhen China"},{"name":"Department of Anesthesiology, The Second Clinical Medical College Jinan University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16213603"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010020\u201001657\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010230182"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0149\u20107634(00)00012\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt222"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30368\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010150117"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2024.1304221"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000204"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2014.08.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12512"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033402"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhae310"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2301707120"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2012.11.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12069"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104886(85)90033\u20100"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735\u20107044.104.1.62"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.58.12.1791"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh400"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010190167"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001051\u20102"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000208053"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204828"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2021.103641"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3275\/7800"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201005752\u20106"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00386"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2.4.399"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(96)00072\u20103"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u20102011\u20100061"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(12)70191\u20106"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15183"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010024\u201006755\u20101"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2026.111737"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11061007"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1380196"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:16:34Z","timestamp":1790331394000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/alz.71874"],"URL":"https:\/\/doi.org\/10.1002\/alz.71874","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71874"}}