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We examined associations between BBMs and quantitative postmortem neuropathology in 124 participants from the Massachusetts Alzheimer's Disease Research Center (MADRC) Longitudinal Cohort Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Plasma phosphorylated tau 217 (p\u2010tau217), p\u2010tau181, total tau (t\u2010tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were measured using the Meso Scale Discovery platform and correlated with postmortem quantitative measures of A\u03b2 plaques, AT8\n                      <jats:sup>+<\/jats:sup>\n                      pTau neurons, cortical thickness, and GFAP\n                      <jats:sup>+<\/jats:sup>\n                      astrocytes across the temporal, frontal, and occipital lobes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau217 strongly associated with A\u03b2 plaques (especially neuritic) and AT8\n                      <jats:sup>+<\/jats:sup>\n                      neurons. Associations were weaker for p\u2010tau181 and t\u2010tau. NfL associated only with lower cortical thickness. GFAP correlated with A\u03b2 plaques, AT8\n                      <jats:sup>+<\/jats:sup>\n                      neurons, and cortical and white matter GFAP\n                      <jats:sup>+<\/jats:sup>\n                      astrocytes. Plasma p\u2010tau217 and GFAP mediated the association between A\u03b2 plaques and AT8\n                      <jats:sup>+<\/jats:sup>\n                      neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings support BBM biological specificity and utility for in vivo characterization of distinct neuropathologic processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71883","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:12:49Z","timestamp":1791533569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between plasma biomarker levels and quantitative postmortem neuropathologic measures in Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1850-0023","authenticated-orcid":false,"given":"Celia R.","family":"Bianco","sequence":"first","affiliation":[{"name":"Neurology Department Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-4256","authenticated-orcid":false,"given":"Neus","family":"Rabaneda\u2010Lombarte","sequence":"additional","affiliation":[{"name":"Neurology Department Mass General Brigham  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadia","family":"Fatima","sequence":"additional","affiliation":[{"name":"Neurology Department Mass General Brigham  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Celedon","sequence":"additional","affiliation":[{"name":"Neurology 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