{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:18Z","timestamp":1791295338202,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG07204401"],"award-info":[{"award-number":["K01AG07204401"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cognitive impairment is a common non\u2010motor symptom of Parkinson's disease (PD), yet the mechanism remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Longitudinal serum samples from PD patients in a community\u2010based case\u2013control study were profiled, with cognition assessed by the Mini\u2010Mental State Examination at baseline and follow\u2010up. We performed three metabolome\u2010wide association studies: a baseline cross\u2010sectional analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0632), a time\u2010to\u2010event analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0412), and a repeated measures analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0265), followed by \u201cMummichog\u201d pathway analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of the 4762 metabolomic features, four reached statistical significance in the baseline analysis, 22 in the time\u2010to\u2010event analysis, and none in the repeated measures analysis. Dysregulated pathways included purine metabolism, the pentose phosphate pathway, fatty acid pathways, and C21\u2010steroid hormone biosynthesis and metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Disruptions in core metabolic pathways may contribute to PD\u2010related cognitive impairments. Disturbances in pentose and purine pathways may occur before clinical cognitive decline is observed, suggesting early metabolic markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71890","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:43:51Z","timestamp":1791294231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7383-100X","authenticated-orcid":false,"given":"Yuyuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Health Policy Research UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irish","family":"Del Rosario","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Duarte Folle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Rose","family":"Mayeda","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California 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