{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:00:51Z","timestamp":1790755251728,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Excitation\u2013inhibition (E\/I) imbalance has been proposed as an early circuit\u2010level mechanism in Alzheimer's disease (AD), but its relationship to molecular pathology and cognition in humans remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We integrated biophysical modeling of resting\u2010state functional magnetic resonance imaging with cerebrospinal fluid (CSF) and plasma biomarkers to examine whether E\/I ratio links amyloid pathophysiology to memory in non\u2010demented individuals across two cohorts from North America (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0302; CSF amyloid beta 42 [A\u03b242]) and Singapore (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0240; plasma phosphorylated tau 217 [p\u2010tau217]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Elevated E\/I ratio was associated with lower CSF A\u03b242 and higher plasma p\u2010tau217, with greater sensitivity in sensory\u2013motor regions. In contrast, elevated E\/I ratio in association cortices was more strongly related to worse memory function. Mediation analyses indicated E\/I ratio partially accounted for the AD biomarker\u2013memory relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>E\/I imbalance represents an intermediate, systems\u2010level circuit mechanism that links AD pathophysiology to cognitive impairment, offering novel insight into early neurophysiological changes along the AD continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71891","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:39:23Z","timestamp":1790753963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excitation\u2013inhibition imbalance links amyloid pathophysiology to cognition in non\u2010demented individuals"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-9150","authenticated-orcid":false,"given":"Shaoshi","family":"Zhang","sequence":"first","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Electrical and Computer Engineering National University of Singapore  Singapore Singapore"},{"name":"Integrative Sciences and Engineering Programme (ISEP) National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-457X","authenticated-orcid":false,"given":"Sebastian N.","family":"Roemer\u2010Cassiano","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research LMU Munich  Munich Germany"},{"name":"Department of Neurology LMU Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Ruifen","family":"Chong","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Memory, Ageing and Cognition Centre Departments of Pharmacology and Psychological Medicine Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9549-0694","authenticated-orcid":false,"given":"Tian","family":"Fang","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8905-7799","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Memory, Ageing and Cognition Centre Departments of Pharmacology and Psychological Medicine Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9252-0083","authenticated-orcid":false,"given":"Ziwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0773-4502","authenticated-orcid":false,"given":"Tianchu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Electrical and Computer Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"},{"name":"Aging Research Center Karolinska Institute and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-7583","authenticated-orcid":false,"given":"Gustavo","family":"Deco","sequence":"additional","affiliation":[{"name":"Center for Brain and Cognition Department of Technology and Information Universitat Pompeu Fabra  Barcelona Spain"},{"name":"Instituci\u00f3 Catalana de la Recerca i Estudis Avan\u00e7ats Universitat Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-6362","authenticated-orcid":false,"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[{"name":"Raffles Neuroscience Centre, Raffles Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0180-8648","authenticated-orcid":false,"given":"Juan Helen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Electrical and Computer Engineering National University of Singapore  Singapore Singapore"},{"name":"Integrative Sciences and Engineering Programme (ISEP) National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-9225","authenticated-orcid":false,"given":"Christopher Li\u2010Hsian","family":"Chen","sequence":"additional","affiliation":[{"name":"Memory, Ageing and Cognition Centre Departments of Pharmacology and Psychological Medicine Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-1424","authenticated-orcid":false,"given":"Mitchell K. P.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-2283","authenticated-orcid":false,"given":"Nicolai","family":"Franzmeier","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research LMU Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg, The Sahlgrenska Academy  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-3276","authenticated-orcid":false,"given":"B. T. Thomas","family":"Yeo","sequence":"additional","affiliation":[{"name":"Centre for Sleep &amp; Cognition &amp; Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Medicine Healthy Longevity Translational Research Programme Human Potential Translational Research Programme &amp; Institute for Digital Medicine (WisDM) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"N.1 Institute for Health &amp; Institute for Digital Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Electrical and Computer Engineering National University of Singapore  Singapore Singapore"},{"name":"Integrative Sciences and Engineering Programme (ISEP) National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70299\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001249\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)01124\u20101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000645\u20106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.03.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv338"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12088"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20109\u201048"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.10.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.600084"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5068\u201013.2014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220\u2010025\u201000502\u20107"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062798\u20104"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000171450.97464.49"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2250\u201006.2006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.023"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010025\u201000736\u20107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.025"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2019.00054"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77850"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21559"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww139"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14528"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010327370"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab163"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14502"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2387"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4485"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1397\u201018.2018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230035"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318641121"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.060"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.007"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.012"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19835565"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12332"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000297"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx224"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3733\u201005.2006"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011204814320"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026704\u2010y"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.040"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.025"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13321"},{"key":"e_1_2_8_52_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/3-540-32494-1_4","volume-title":"Towards a New Evolutionary Computation Studies in Fuzziness and Soft Computing","author":"Hansen N","year":"2006"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.08.047"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010023\u201001282\u2010y"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.077713"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172914.08967.dc"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100127\u2010z"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv236"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100289\u20108"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100687\u20106"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014159\u20101"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23650"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100483\u20104"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.046"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016710\u2010x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.006"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100426\u20100"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102553"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(25)00227\u20103"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa286"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213769"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114022"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002074\u2010w"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.74"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00046"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.02.006"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2007.05598.x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70277\u20105"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.373"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(03)00530\u20101"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20730"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww015"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15007"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001150\u2010x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000405\u20101"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010025\u201002000\u20106"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008315"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210820125543"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30490\u20103"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010019\u201000580\u2010x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.10.034"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21049"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2026.100615"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251389006"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:39:24Z","timestamp":1790753964000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":96,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/alz.71891"],"URL":"https:\/\/doi.org\/10.1002\/alz.71891","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71891"}}