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GM microstructural alterations in posterior cortical regions were associated with worse memory when controlling for Alzheimer's proteinopathies. GM microstructural alterations mediated the relationship between Alzheimer's proteinopathies and memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>GM microstructural alterations have functional ramifications given their mediating effect on the relationship between Alzheimer's proteinopathies and memory and their association with worse memory beyond Alzheimer's proteinopathies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71899","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:57:52Z","timestamp":1791946672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7544-6328","authenticated-orcid":false,"given":"Quentin","family":"Devignes","sequence":"first","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Petscavage","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Koeppe","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neurology Service and Geriatric Research Education and Clinical Center VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Peltier","sequence":"additional","affiliation":[{"name":"Functional MRI Laboratory Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Biomedical Engineering University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalise","family":"Rahman\u2010Filipiak","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Giordani","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru D.","family":"Iordan","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Hampstead","sequence":"additional","affiliation":[{"name":"Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry University of Michigan  Ann Arbor Michigan 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