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<jats:italic>post\u2010mortem<\/jats:italic>\n                      brain proteomics from Religious Orders Study and Rush Memory and Aging Project (ROS\/MAP) and cerebrospinal fluid (CSF) proteomics from Alzheimer's Disease Neuroimaging Initiative (ADNI) to identify CAA\u2010associated proteins and network modules, delineate their biological processes and cellular origins, and determine their diagnostic performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Proteomics analysis identified 30 proteins as associated with CAA severity, enriched in pathways distinct from AD pathology, with 11 replicated in ADNI. Two CAA\u2010associated modules were enriched for microglial vesicle transport and astrocytic potassium\u2010ion homeostasis. Pseudotime analysis demonstrated a molecular trajectory aligned with increasing CAA severity. Three proteins (RCSD1, FRZB, AKAP6) improved CAA classification beyond demographics and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This integrative proteomics analysis identifies distinct, reproducible molecular signatures of CAA, revealing glia\u2010mediated pathways and promising biomarkers for CAA detection and therapy\u2010related risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71901","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:41:21Z","timestamp":1791531681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic dysregulation associated with cerebral amyloid 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