{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:50:58Z","timestamp":1791532258973,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Farming populations may face a disproportionate share of adverse exposures influencing Alzheimer's disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early\u2010life exposure is related to AD neuropathology is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHOD<\/jats:title>\n                    <jats:p>\n                      Brain donors from two Alzheimer's Disease Research Centers (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a01035; between 1986\u20132018) were included. US Census records were used to identify those with early\u2010life farming exposure (birth to 17 years old) and examined alongside AD neuropathology assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULT<\/jats:title>\n                    <jats:p>Early\u2010life farming exposure (\u2248 17% of donors) was associated with 60% higher odds of AD neuropathological burden (odds ratio\u00a0=\u00a01.60, 95% confidence interval: 1.09\u20132.35) adjusting for age, sex, and year of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Findings suggest exposure to farming early in life is linked to increased levels of AD neuropathology. Deeper occupational and residential phenotyping is needed to identify the potential multiple, overlapping risk pathways, which may include cumulative and sensitive life stage exposure to chemical toxicants, hearing loss, and psychosocial hazards.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71904","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:32:22Z","timestamp":1791531142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between early\u2010life farming exposure and Alzheimer's disease neuropathological burden"],"prefix":"10.1002","volume":"22","author":[{"given":"W. 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Shahriar","family":"Salamat","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Bradfield","sequence":"additional","affiliation":[{"name":"Molecular &amp; Environmental Toxicology Center University of Wisconsin  Madison Wisconsin USA"},{"name":"Biotechnology Center University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Goutman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan 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