{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:45:03Z","timestamp":1791949503005,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019889","name":"Weston Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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Baseline gray matter volume (GMV) was compared by sex. In ADNI, tau positron emission tomography burden and cerebrospinal fluid growth\u2010associated protein 43 (GAP\u201043) were assessed. Longitudinal analyses examined atrophy and conversion from MCI to dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Females with MCI exhibited greater baseline GMV than males primarily in the thalamus, caudate, cerebellum, postcentral gyrus, and middle cingulate gyrus, with no differences at the AD stage. Despite this, females exhibited higher baseline GAP\u201043, greater tau burden in temporal and parietal regions, and more rapid annual hippocampal atrophy. Conversion rates were similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings suggest that females may tolerate greater pathology at early stages but experience faster neurodegeneration later, supporting sex\u2010specific disease trajectories and highlighting the need for sex\u2010informed biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71913","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:49:06Z","timestamp":1791946146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia"],"prefix":"10.1002","volume":"22","author":[{"given":"Xulin","family":"Liu","sequence":"first","affiliation":[{"name":"Krembil Research Institute University Health Network  Toronto Ontario Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterre C. M.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam the Netherlands"},{"name":"School of Psychology and Brain &amp; Mind Centre The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Krembil Research Institute University Health Network  Toronto Ontario Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging 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