{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:52:14Z","timestamp":1770760334100,"version":"3.50.0"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n There has been a recent focus within Alzheimer's Disease (AD) research on potential CSF biomarkers as diagnostic tools. PET imaging and CSF biomarkers have been used to determine the amyloid status of individuals when characterising AD. While these measures have largely correlated with each other, it is also suggested that there could be patients who can have discordant results. However, it is still unclear what proportion of AD subjects demonstrate the discordance. Additionally, whether these changes are associated with different pathological and clinical characteristics of the patients. Here, we investigated the discordance between CSF A\u03b242:40 and amyloid status and evaluated whether there are any significant changes in their levels of tau aggregation.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n 313 participants\u2019 data were selected from the ADNI database. The cutoff for A\u03b242:40 was then calculated using the Youden Index resulting from receiver operating characteristic (ROC) curve. The formula used was\n J<\/jats:italic>\n \u00a0=\u00a0max\n c<\/jats:italic>\n {Se (\n c<\/jats:italic>\n ) + Sp (\n c<\/jats:italic>\n ) \u2212 1}, resulting in a maximum cutoff of\n J<\/jats:italic>\n \u00a0=\u00a00.057 for A\u03b242:40. This cutoff produced a discordance rate of 10.5%, with\n n<\/jats:italic>\n \u00a0=\u00a033 of 313 patients being discordant. We then performed t\u2010tests to investigate the potential clinical differences between concordant and discordant patients.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Independent samples t\u2010tests indicated that levels of pTau181 and total Tau significantly differed between the concordant and discordant groups. pTau181 was significantly lower in the discordant group (t(71.2)=\u20103.166,\n p<\/jats:italic>\n \u00a0=\u00a0.002), as was Tau (t(53.9)=\u20102.046,\n p<\/jats:italic>\n \u00a0=\u00a0.046). Further data is found in Figure 1.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Demonstration of different levels of tau deposition in the discordant groups implies there may be other pathological processes influencing neurodegeneration in these subjects. A discordance of 10% between CSF amyloid and PET amyloid implies that we should evaluate these subjects in greater detail before enrolling them in intervention studies.<\/jats:p>\n \n References<\/jats:bold>\n <\/jats:p>\n \n 1. Hansson, O. et al. (2019).\n https:\/\/doi.org\/10.1186\/s13195\u2010019\u20100485\u20100<\/jats:ext-link>\n <\/jats:p>\n \n 2. Pyun, JM. et al. (2024)\n https:\/\/doi.org\/10.1038\/s41398\u2010024\u201002766\u20106<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70856_106931","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:37:21Z","timestamp":1769110641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discordance between CSF amyloid beta and PET\u2010derived amyloid status and its clinical implications"],"prefix":"10.1002","volume":"21","author":[{"given":"Gemma Natalie","family":"Wright","sequence":"first","affiliation":[{"name":"Imperial College London, London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Neil","family":"Dodds","sequence":"additional","affiliation":[{"name":"Imperial College London, London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifa Sanjida","family":"Punnota","sequence":"additional","affiliation":[{"name":"Imperial College London, London, Greater London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vicidomini","sequence":"additional","affiliation":[{"name":"Imperial College London, London, Greater London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Edison","sequence":"additional","affiliation":[{"name":"Imperial College London, London, Greater London, United Kingdom"},{"name":"Division of Neurology, Department of Brain Sciences, Imperial College London, United Kingdom, London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_106931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz70856_106931","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_106931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:10:02Z","timestamp":1770700202000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70856_106931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70856_106931"],"URL":"https:\/\/doi.org\/10.1002\/alz70856_106931","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e106931"}}