{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:08:36Z","timestamp":1770685716289,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Mild Behavioral Impairment (MBI) involves the late\u2010onset, sustained emergence of neuropsychiatric symptoms (NPS) in predementia populations. Prior studies examining amyloid and tau PET in relation to MBI have shown a link to amyloid burden but not to tau. However, the role of plasma biomarkers in MBI remains uncertain. In this study, we aimed to determine whether MBI is associated with plasma\n p<\/jats:italic>\n \u2010tau217 levels in older adults without dementia.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n We included 168 older adults (136 cognitively unimpaired [CU] and 32 with mild cognitive impairment [MCI] ) from the TRIAD cohort. Participants had amyloid status assessed by [18F]AZD4694 A\u03b2\u2010PET. Plasma\n p<\/jats:italic>\n \u2010tau217 levels were quantified using the Janssen Simoa Assay. MBI was assessed using the Mild Behavioral Impairment Checklist (MBI\u2010C), global cognition was measured with the Mini\u2010Mental State Examination (MMSE) and the sum of boxes of the Clinical Dementia Rating (CDR\u2010SB). Multivariable linear regression analyses examined associations between plasma\n p<\/jats:italic>\n \u2010tau217 and MBI\u2010C total and subdomain scores, adjusting for age, sex, and CDR\u2010SB.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n When controlling for age and sex, higher\n p<\/jats:italic>\n \u2010tau217 levels were significantly associated with increased MBI\u2010C total (\u03b2\u00a0=\u00a015.97,\n p<\/jats:italic>\n \u00a0=\u00a0 0.03), emotion dysregulation (\u03b2\u00a0=\u00a05.98,\n p<\/jats:italic>\n \u00a0=\u00a0 0.017), and impulse dyscontrol (\u03b2\u00a0=\u00a07.92,\n p<\/jats:italic>\n \u00a0=\u00a0 0.012). However, these associations did not remain significant once CDR\u2010SB was included in the model. Instead, MBI\u2010C total and its subdomains emotion dysregulation, impulse dyscontrol, and motivation were related only to cognitive status.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings suggest that\n p<\/jats:italic>\n \u2010tau217 could play a role in MBI, particularly in the impulse dyscontrol and emotion dysregulation domains, neuropsychiatric symptoms which have been previously linked to Alzheimer's disease. However, overall cognitive status emerged as the strongest predictor of these behavioral symptoms in older adults. Further research is warranted to clarify how\n p<\/jats:italic>\n \u2010tau217 levels and cognitive decline interact to influence the risk and progression of MBI.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70856_107716","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:00:21Z","timestamp":1769112021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship of Plasma\n p<\/i>\n \u2010tau217 and Mild Behavioral Impairment in Elderly Individuals Without Dementia"],"prefix":"10.1002","volume":"21","author":[{"given":"Ana Paula Bernardes","family":"Real","sequence":"first","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montr\u00e9al, QC, Canada"},{"name":"Department of Geriatrics, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur C.","family":"Macedo","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"McGill University Research Centre for Studies in Aging, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wyllians Vendramini","family":"Borelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"},{"name":"Brain Institute of Rio Grande do Sul (InsCer), PUCRS, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tevy","family":"Chan","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrine","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"The McGill University Research Centre for Studies in Aging, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Aumont","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleb","family":"Bezgin","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Lu","family":"Jia","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J","family":"Hall","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart William","family":"Mitchell","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Stevenson","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"The McGill University Research Centre for Studies in Aging, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Trudel","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Marier","sequence":"additional","affiliation":[{"name":"University of Montreal, Montreal, QC, Canada"},{"name":"Douglas Research Centre, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Levinoff","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Morais","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Rosa\u2010Neto","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"},{"name":"Montreal Neurological Institute, Montr\u00e9al, QC, Canada"},{"name":"Translational Neuroimaging Laboratory, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_107716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz70856_107716","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_107716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:41:35Z","timestamp":1770622895000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70856_107716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70856_107716"],"URL":"https:\/\/doi.org\/10.1002\/alz70856_107716","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e107716"}}