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Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Liver weight of 506 mice generated from 39 different Collaborative Cross (\n CC<\/jats:styled-content>\n ) lines with both sexes at age 20\u00a0weeks old was determined using an electronic balance. Genomic\n DNA<\/jats:styled-content>\n of the\n CC<\/jats:styled-content>\n lines was genotyped with high\u2010density single nucleotide polymorphic markers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Statistical analysis revealed a significant (\n P<\/jats:italic>\n \u00a0<\u00a00.05) variation of liver weight between the\n CC<\/jats:styled-content>\n lines, with broad sense heritability (\n H<\/jats:italic>\n 2<\/jats:sup>\n ) of 0.32 and genetic coefficient of variation (\n \n CV\n G<\/jats:sub>\n <\/jats:styled-content>\n ) of 0.28. Subsequently, quantitative trait locus (\n QTL<\/jats:styled-content>\n ) mapping was performed, and results showed a significant\n QTL<\/jats:styled-content>\n only for females on chromosome 8 at genomic interval 88.61\u201093.38\u00a0Mb (4.77\u00a0Mb). Three suggestive\n QTL<\/jats:styled-content>\n were mapped at chromosomes 4, 12 and 13. The four\n QTL<\/jats:styled-content>\n were designated as\n \n LWL<\/jats:styled-content>\n <\/jats:italic>\n 1\u2010\n \n LWL<\/jats:styled-content>\n <\/jats:italic>\n 4 referring to liver weight loci 1\u20104 on chromosomes 8, 4, 12 and 13, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n To our knowledge, this report presents, for the first time, the utilization of the\n CC<\/jats:styled-content>\n for mapping\n QTL<\/jats:styled-content>\n associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ame2.12036","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T22:13:16Z","timestamp":1540419196000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice"],"prefix":"10.1002","volume":"1","author":[{"given":"Hanifa J.","family":"Abu\u2010Toamih Atamni","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Botzman","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences Tel\u2010Aviv University Tel\u2010Aviv 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