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Other analogs have not been used in rodents. We aimed to evaluate the effects and mechanisms of intraperitoneal (ip) amprolium\u2010induced\n                      <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                      in mice. We also evaluated the associated pathogenesis using antioxidant and anti\u2010inflammatory compounds (Trolox, dimethyl sulfoxide).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male mice were separated into two groups, one receiving a standard diet (control animals), and the other a\n                      <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                      diet (deficient groups) for 20\u00a0days. Control mice were further subdivided into three groups receiving daily ip injections of saline (NaCl 0.9%; Cont group), Tolox (Tr group) or dimethyl sulfoxide (\n                      <jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>\n                      ; Dmso group). The three\n                      <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                      groups received amprolium (Amp group), amprolium and Trolox (Amp+Tr group), or amprolium and\n                      <jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>\n                      (Amp+Dmso group). The animals were subjected to behavioral tests and then euthanized. The brain and viscera were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amprolium exposure induced weight loss with hyporexia, reduced the behavioral parameters (locomotion, exploratory activity, and motor coordination), and induced changes in the brain (lower cortical cell viability) and liver (steatosis). Trolox co\u2010treatment partially improved these conditions, but to a lesser extent than\n                      <jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Amprolium\u2010induced\n                      <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                      may be an interesting model, allowing the deficiency to develop more slowly and to a lesser extent. Amprolium exposure also seems to involve oxidative stress and inflammation, suggested as the main mechanisms of cell dysfunction in\n                      <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.12040","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T14:48:23Z","timestamp":1542811703000},"page":"272-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Amprolium exposure alters mice behavior and metabolism in\u00a0vivo"],"prefix":"10.1002","volume":"1","author":[{"given":"Juliana Oliveira","family":"Moraes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sanidade Animal e Sa\u00fade P\u00fablica nos Tr\u00f3picos Universidade Federal do Tocantins Aragua\u00edna TO 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