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Previous studies show alcohol disrupts fracture associated Wnt signaling required for normal bone fracture repair. Intermittent parathyroid hormone (PTH) promotes bone growth through canonical Wnt signaling, however, no studies have investigated the effect of PTH on alcohol\u2010inhibited bone fracture repair. Male C57BL\/6 mice received two\u20103\u00a0day alcohol binges separated by 4\u00a0days before receiving a mid\u2010shaft tibia fracture. Postoperatively, mice received PTH daily until euthanasia. Wnt\/\u03b2\u2010catenin signaling was analyzed at 9\u00a0days post\u2010fracture. As previously observed, acute alcohol exposure resulted in a &gt;2\u2010fold decrease in total and the active form of \u03b2\u2010catenin and a 2\u2010fold increase in inactive \u03b2\u2010catenin within the fracture callus. Intermittent PTH abrogated the effect of alcohol on \u03b2\u2010catenin within the fracture callus. Upstream of \u03b2\u2010catenin, alcohol\u2010treated animals had a 2\u2010fold decrease in total LRP6, the Wnt co\u2010receptor, which was restored with PTH treatment. Alcohol nor PTH had any significant effect on GSK\u20103\u03b2. These data show that intermittent PTH following a tibia fracture restores normal expression of Wnt signaling proteins within the fracture callus of alcohol\u2010treated mice.<\/jats:p>","DOI":"10.1002\/ame2.12116","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T06:02:49Z","timestamp":1588917769000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alcohol\u2010induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment"],"prefix":"10.1002","volume":"3","author":[{"given":"Esha M.","family":"Kapania","sequence":"first","affiliation":[{"name":"Internal Medicine\u2010Pediatric Resident Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor J.","family":"Reif","sequence":"additional","affiliation":[{"name":"Limb Lengthening and Complex 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