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Low back pain and other spine disorders are prevalent among those exposed to whole\u2010body vibration in occupational and military settings. Although standards for limiting exposure to whole\u2010body vibration have been in place for decades, there is a lack of understanding of whole\u2010body vibration\u2010associated risks among safety and healthcare professionals. Consequently, disorders associated with whole\u2010body vibration exposure remain prevalent in the workforce and military. The relationship between whole\u2010body vibration and low back pain in humans has been established largely through cohort studies, for which vibration inputs that lead to symptoms are rarely, if ever, quantified. This gap in knowledge highlights the need for the development of relevant in vivo, ex vivo, and in vitro models to study such pathologies. The parameters of vibrational stimuli (eg, frequency and direction) play critical roles in such pathologies, but the specific cause\u2010and\u2010effect relationships between whole\u2010body vibration and spinal pathologies remain mostly unknown. This paper provides a summary of whole\u2010body vibration parameters; reviews in vivo, ex vivo, and in vitro models for spinal pathologies resulting from whole\u2010body vibration; and offers suggestions to address the gaps in translating injury biomechanics data to inform clinical practice.<\/jats:p>","DOI":"10.1002\/ame2.12163","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:19:39Z","timestamp":1616483979000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Deleterious effects of whole\u2010body vibration on the spine: A review of in vivo, ex vivo, and in vitro models"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0613-8804","authenticated-orcid":false,"given":"Folly","family":"Patterson","sequence":"first","affiliation":[{"name":"Department of Agricultural and Biological Engineering Mississippi State University Mississippi State MS USA"},{"name":"Center for Advanced Vehicular Systems Mississippi State University Starkville MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheleh","family":"Miralami","sequence":"additional","affiliation":[{"name":"Center for Advanced Vehicular Systems Mississippi State University Starkville MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E.","family":"Tansey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurobiology University of Mississippi Medical Center Jackson MS USA"},{"name":"Center for Neuroscience and Neurological Recovery Methodist Rehabilitation Center Jackson MS USA"},{"name":"Spinal Cord Injury Medicine and Research Services G.V. 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