{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:53:01Z","timestamp":1792428781966,"version":"4.5.0"},"reference-count":183,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970777"],"award-info":[{"award-number":["31970777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens. As a heterogeneous disease with complex pathophysiology, mimicking all aspects of human stroke in one animal model is impossible. Each model has unique strengths and weaknesses. Models such as transient or permanent intraluminal thread occlusion middle cerebral artery occlusion (MCAo) models and thromboembolic models are the most commonly used in simulating human ischemic stroke. The endovascular filament occlusion model is characterized by easy manipulation and accurately controllable reperfusion and is suitable for studying the pathogenesis of focal ischemic stroke and reperfusion injury. Although the reproducibility of the embolic model is poor, it is more convenient for investigating thrombolysis. Rats are the most frequently used animal model for stroke. This review mainly outlines the stroke models of rats and discusses their strengths and shortcomings in detail.<\/jats:p>","DOI":"10.1002\/ame2.12179","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T05:54:45Z","timestamp":1631685285000},"page":"204-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":187,"title":["Animal models of stroke"],"prefix":"10.1002","volume":"4","author":[{"given":"Yanyu","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Guangdong Medical University &amp; Key Laboratory of Zebrafish Model for Development and Diseases of Guangdong Medical University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-4638","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guangdong Medical University &amp; Key Laboratory of Zebrafish Model for Development and Diseases of Guangdong Medical University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"},{"key":"e_1_2_7_3_1","first-page":"386","article-title":"Ischemic stroke in young adults","volume":"26","author":"Putaala J","year":"2020","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001119"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2019.07.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.9.1083"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3934754"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.00584"},{"key":"e_1_2_7_10_1","first-page":"34","article-title":"Animal models of ischemic stroke. 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