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These levels correspond to disrupted metabolism and decreased protein synthesis but did not exceed thresholds for electrical signaling or membrane integrity. This may partially explain how some episodes of elevated ICP remain benign.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The closed cranial window model provides a platform for prospective study of physiologic responses to artificially elevated ICP during neurosurgery to promote hemostasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12187","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T05:43:40Z","timestamp":1637387020000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Closed cranial window rodent model for investigating hemodynamic response to elevated intracranial pressure"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-2220","authenticated-orcid":false,"given":"Matt T.","family":"Oberdier","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Carnegie 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