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Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease (LHD). Clinically, there are no drugs or treatments that directly address PH\u2010LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH\u2010LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH\u2010LHD are required. There are several available models for PH\u2010LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH\u2010LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH\u2010LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH\u2010LHD. Therefore, this review will summarize the characteristics of each PH\u2010LHD animal model and discuss the advantages and limitations of the different models.<\/jats:p>","DOI":"10.1002\/ame2.12214","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T08:08:08Z","timestamp":1644394088000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Animal models of pulmonary hypertension due to left heart disease"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-5938","authenticated-orcid":false,"given":"Shao\u2010Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin 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