{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:21:45Z","timestamp":1747146105480,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BioCen\u2010128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer's disease (AD), where the inflammation plays an important role. Because of the anti\u2010inflammatory potential of BioCen\u2010128, the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular (ICV) administration of streptozotocin (STZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The experiment was carried out using male OF\u20101<jats:sub>cenp<\/jats:sub> mice weighing 20\u2009\u00b1\u20092\u00a0g.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice administered BioCen\u2010128 in via the IP route at 5, 10 and 20\u2009mg\/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti\u2010inflammatory effect. In the ICV model of STZ, the administration of BioCen\u2010128 improved cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These responses suggested an anti\u2010neuroinflammatory effect explainable by the action of thymosin \u03b24 and thymosin alfa proteins. The results suggested that BioCen\u2010128 could be used in the prevention and treatment of some diseases, for example AD, where neuroinflammation is one of the biological events that take place.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12267","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T06:13:20Z","timestamp":1660630400000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential anti neuro\u2010inflammatory effect of BioCen\u2010128 in animal models of dementia"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-0007","authenticated-orcid":false,"given":"Nashelly","family":"Esquivel","sequence":"first","affiliation":[{"name":"National Center for Bioproducts (BIOCEN)  Bejucal Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenela","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"National Center for Bioproducts (BIOCEN)  Bejucal Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Center for Neurosciences (CNEURO)  Playa Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teidy E.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Center for Neurosciences (CNEURO)  Playa Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana R.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Marine Sciences (ICIMAR)  Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"National Center for Bioproducts (BIOCEN)  Bejucal Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"110301","article-title":"In search of a germ theory equivalent for chronic disease","volume":"9","author":"Egger G","year":"2012","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03261.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.03.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00165-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.63"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03261.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2003.10.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/142087"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0291-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.801"},{"issue":"1","key":"e_1_2_11_15_1","first-page":"6","article-title":"Efecto anti\u2010inflamatorio de la terapia combinada del D\u2010002 y Lyprinol en un modelo de inflamaci\u00f3n cr\u00f3nica","volume":"48","author":"Rodr\u00edguez ZZ","year":"2017","journal-title":"Rev CENIC Cienc Biol"},{"key":"e_1_2_11_16_1","unstructured":"ALZFORUM. 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