{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:32:58Z","timestamp":1790645578971,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700045"],"award-info":[{"award-number":["81700045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000059"],"award-info":[{"award-number":["82000059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The association between blood eosinophil (EOS) counts and arterial\/venous thrombosis is unclear. We aim to explore whether EOS count is a risk factor for thrombosis. We searched several databases and preprint platforms using core terms \u2018eosinophil\u2019, \u2018myocardial infarction\u2019, \u2018ischemic stroke\u2019, and \u2018venous thromboembolism\u2019 (VTE), among others. Studies comparing the odds ratios (ORs) or risk ratios (RRs) of EOSs with the abovementioned diseases were eligible. Overall, 22 studies were included. A high EOS count was associated with acute coronary artery thrombosis events (OR: 1.23, 95% CI: 1.15\u20131.32), short\u2010term cerebral infarction and mortality (RR: 2.87, 95% CI: 1.49\u20135.51). The short\u2010term risk of VTE was more common in patients with EOS\u2010related diseases (RR: 6.52, 95% CI: 2.42\u201317.54). For coronary artery disease, a high EOS count was a protective factor against 6\u2010month to 1\u2010year mortality (RR: 0.56, 95% CI: 0.45\u20130.69) but was associated with long\u2010term mortality (RR: 1.64, 95% CI: 1.25\u20132.14). Therefore, we conclude that for coronary artery thrombosis, EOS count is not associated with AMI events in general population. It may be associated with NSTEMI and STEMI in CAD patients, but more studies are needed to confirm this. In addition, EOS count is associated with an increased risk of both short\u2010 and long\u2010term mortality but is not predictive of the composite endpoints. For cerebral artery thrombosis, EOS count may be associated with cerebral infarction and could lead to an increased risk of poor short\u2010term prognosis. For VTEs, EOS count was a risk factor for some patients, especially those with acute\u2010phase EOS\u2010related diseases.<\/jats:p>","DOI":"10.1002\/ame2.12277","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T06:14:20Z","timestamp":1665123260000},"page":"470-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Arterial and venous thromboembolism risk associated with blood eosinophils: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-0343","authenticated-orcid":false,"given":"Wei\u2010Jie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai 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