{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:06:06Z","timestamp":1787501166443,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects. The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug\u2010induced hepatosis and hepatitis in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We modeled diclofenac\u2010induced hepatitis and tetracycline\u2010induced hepatosis. Hemostasis response was gauged by measuring fibrinogen, factor X, protein C (PC), and prothrombin in plasma. The decarboxylated form of prothrombin was detected by measuring prothrombin index and ecamulin index. Platelet reactivity was studied using aggregometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both hepatitis and hepatosis decreased the synthesis of fibrinogen, factor X, and prothrombin. However, protein carboxylation was not disrupted in hepatosis but was much impaired in hepatitis. PC decreased in both models as a consequence of its consumption possibly during inflammatory response. Platelet aggregation rate was lower in hepatosis but higher in hepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic complications. Its state indicates the disorder's rate and character.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.12301","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T11:45:42Z","timestamp":1672141542000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blood coagulation factors and platelet response to drug\u2010induced hepatitis and hepatosis in rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Daria","family":"Korolova","sequence":"first","affiliation":[{"name":"Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-1392","authenticated-orcid":false,"given":"Viktoriya","family":"Gryshchenko","sequence":"additional","affiliation":[{"name":"National University of Life and Environmental Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Chernyshenko","sequence":"additional","affiliation":[{"name":"Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-6055","authenticated-orcid":false,"given":"Oleh","family":"Platonov","sequence":"additional","affiliation":[{"name":"Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha","family":"Hornytska","sequence":"additional","affiliation":[{"name":"Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr","family":"Chernyshenko","sequence":"additional","affiliation":[{"name":"Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo","family":"Klymenko","sequence":"additional","affiliation":[{"name":"SI \u201cD.F. 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