{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T19:09:36Z","timestamp":1774811376665,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl<jats:sub>2<\/jats:sub>). This study was designed to investigate the role of glycine in the mitigation of hepato\u2010renal toxicities associated with CoCl<jats:sub>2<\/jats:sub> exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two (42) male rats were grouped as Control; (CoCl<jats:sub>2<\/jats:sub>; 300\u2009ppm); CoCl<jats:sub>2<\/jats:sub>\u2009+\u2009Glycine (50\u2009mg\/kg); CoCl<jats:sub>2<\/jats:sub>\u2009+\u2009Glycine (100\u2009mg\/kg); Glycine (50\u2009mg\/kg); and Glycine (100\u2009mg\/kg). The markers of hepatic and renal damage, oxidative stress, the antioxidant defense system, histopathology, and immunohistochemical localization of neutrophil gelatinase associated lipocalin (NGAL) and renal podocin were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Glycine significantly reduced the markers of oxidative stress (malondialdehyde content and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> generation), liver function tests (ALT, AST, and ALP), markers of renal function (creatinine and BUN), and decreased the expression of neutrophil gelatinase\u2010associated lipocalin (NGAL) and podocin compared with rats exposed to CoCl<jats:sub>2<\/jats:sub> toxicity without glycine treatment. Histopathology lesions including patchy tubular epithelial necrosis, tubular epithelial degeneration and periglomerular inflammation in renal tissues, and severe portal hepatocellular necrosis, inflammation, and duct hyperplasia were observed in hepatic tissues of rats exposed to CoCl<jats:sub>2<\/jats:sub> toxicity, but were mild to absent in glycine\u2010treated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study clearly demonstrate protective effects of glycine against CoCl<jats:sub>2<\/jats:sub>\u2010induced tissue injuries and derangement of physiological activities of the hepatic and renal systems in rats. The protective effects are mediated via augmentation of total antioxidant capacity and upregulation of NGAL and podocin expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12315","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T16:09:51Z","timestamp":1683216591000},"page":"168-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ameliorative effects of glycine on cobalt chloride\u2010induced hepato\u2010renal toxicity in rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Oluwafikemi Temitayo","family":"Iji","sequence":"first","affiliation":[{"name":"Federal College of Animal Health and Production Technology Moor Plantation  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary 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