{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:40:04Z","timestamp":1781271604042,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonalcoholic steatohepatitis (NASH) is characterized by liver steatosis, inflammation, and even fibrosis. NASH is likely to develop into cirrhosis and liver cancer, the major causes of liver related deaths. We aimed to study the effect of probiotics on NASH via the gut\u2010liver axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty male Sprague\u2013Dawley rats were divided into three groups. A control group of 10 rats was fed on a standard chow for 16\u2009weeks. Twenty rats fed on a high\u2010fat diet for 8\u2009weeks were separated to two groups: a model group (10 rats) fed on vehicle for 8\u2009weeks and a treatment group (10 rats) supplemented with binary <jats:italic>Bacillus subtilis<\/jats:italic> for 8\u2009weeks. Hepatic expression of IL\u20106 and TNF\u2010\u0251 and ileum expression of IL\u201017 and occludin were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high\u2010fat diet caused inflammation of the liver and ileum in rats. Binary <jats:italic>Bacillus subtilis<\/jats:italic> treatment reduces liver inflammation through the intestinal liver axis. Increased levels of IL\u20106 and TNF\u2010\u03b1 were detected in rats fed a high\u2010fat diet, which were reduced to lower levels after treatment with binary <jats:italic>Bacillus subtilis<\/jats:italic>. In rats on the high\u2010fat diet, elevated IL\u201017 levels and decreased occludin levels were observed. Treatment with <jats:italic>Bacillus subtilis<\/jats:italic> reduced IL\u201017 levels and restored the expression of occludin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Binary <jats:italic>Bacillus subtilis<\/jats:italic> has a beneficial effect on liver inflammation and intestinal damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12337","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T07:40:41Z","timestamp":1689838841000},"page":"362-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Binary <i>Bacillus subtilis<\/i> protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Donglin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-6311","authenticated-orcid":false,"given":"Pengguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29724"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101167"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01709-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.114"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.02.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz042"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112642"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50048"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33593"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1518"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518189113"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/807356"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2947-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.06.022"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.85"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08096"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.073"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.161"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.01.001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175406"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.12337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:25:46Z","timestamp":1720416346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.12337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/ame2.12337"],"URL":"https:\/\/doi.org\/10.1002\/ame2.12337","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]},"assertion":[{"value":"2023-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}