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The aim of this study was to search for candidate genes associated with host susceptibility to <jats:italic>Aspergillus fumigatus<\/jats:italic> (Af) using an RNAseq approach in CC lines and hepatic gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 31 male mice from 25 CC lines at 8\u2009weeks old; the mice were infected with Af. Liver tissues were extracted from these mice 5\u2009days post\u2010infection, and next\u2010generation RNA\u2010sequencing (RNAseq) was performed. The GENE\u2010E analysis platform was used to generate a clustered heat map matrix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant variation in body weight changes between CC lines was observed. Hepatic gene expression revealed 12 top prioritized candidate genes differentially expressed in resistant versus susceptible mice based on body weight changes. Interestingly, three candidate genes are located within genomic intervals of the previously mapped quantitative trait loci (QTL), including Gm16270 and Stox1 on chromosome 10 and Gm11033 on chromosome 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards Af. As a next step, eQTL analysis will be performed for our RNA\u2010Seq data. Suggested candidate genes from our study will be further assessed with a human cohort with aspergillosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12386","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T04:04:25Z","timestamp":1707969865000},"page":"36-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identifying genetic susceptibility to <i>Aspergillus fumigatus<\/i> infection using collaborative cross mice and <scp>RNA\u2010Seq<\/scp> approach"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-7171","authenticated-orcid":false,"given":"Roa'a H. 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