{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:21:23Z","timestamp":1781716883785,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH021"],"award-info":[{"award-number":["ZR2019MH021"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970385"],"award-info":[{"award-number":["81970385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thromboelastography (TEG) is a widely utilized clinical testing method for real\u2010time monitoring of platelet function and the thrombosis process. Lipid metabolism disorders are crucial risk factors for thrombosis. The lipid metabolism characteristics of hamsters resemble those of humans more closely than mice and rats, and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to plasma lipid mechanisms. Whole blood samples from golden Syrian hamsters and healthy humans were obtained following standard clinical procedures. TEG was employed to evaluate coagulation factor function, fibrinogen (Fib) function, platelet function, and the fibrinolytic system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The whole blood from hamster or healthy human was isolated following the clinical procedure, and TEG was employed to evaluate the coagulation factor function, Fib function, platelet function, and fibrinolytic system. Coagulation analysis used ACLTOP750 automatic coagulation analysis pipeline. Blood routine testing used XN\u20102000 automatic blood analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TEG parameters revealed that hamsters exhibited stronger coagulation factor function than humans (reaction time [R], <jats:italic>p<\/jats:italic>\u2009=\u20090.0117), with stronger Fib function (alpha angle, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; K\u2010time [K], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Platelet function did not differ significantly (maximum amplitude [MA], <jats:italic>p<\/jats:italic>\u2009=\u20090.077). Hamsters displayed higher coagulation status than humans (coagulation index [CI], <jats:italic>p<\/jats:italic>\u2009=\u20090.0023), and the rate of blood clot dissolution in hamsters differed from that in humans (percentage lysis 30\u2009min after MA, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Coagulation analysis parameters indicated that prothrombin time (PT) and activated partial thromboplastin time (APTT) were faster in hamsters than in humans (PT, <jats:italic>p<\/jats:italic>\u2009=\u20090.0014; APTT, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), whereas the Fib content was significantly lower in hamsters than in humans (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). No significant difference was observed in thrombin time (<jats:italic>p<\/jats:italic>\u2009=\u20090.1949).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, TEG could be used to evaluate thrombosis and bleeding parameters in whole blood samples from hamsters. The platelet function of hamsters closely resembled that of humans, whereas their coagulation function was significantly stronger.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12403","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T04:44:01Z","timestamp":1716266641000},"page":"570-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative studies between humans and golden Syrian hamsters via thromboelastography"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5719-5755","authenticated-orcid":false,"given":"Ze","family":"Yang","sequence":"first","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"},{"name":"The Second Affiliated Hospital of Shandong First Medical University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ba","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"},{"name":"The Second Affiliated Hospital of Shandong First Medical University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Zan","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal &amp; Shandong Laboratory Animal Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.06.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010140"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110426"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025092"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135634"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34329-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(91)90263-C"},{"key":"e_1_2_11_9_1","volume-title":"Thromboelastography","author":"Shaydakov ME","year":"2022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1927881"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02240-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003730"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020172"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0214"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1319768"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2014.09.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12241"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000031340.68494.34"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002924"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1298-z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677218811059"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.04.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7196-1_39"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.12403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T04:20:02Z","timestamp":1725596402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.12403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ame2.12403"],"URL":"https:\/\/doi.org\/10.1002\/ame2.12403","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}