{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:11:11Z","timestamp":1790104271448,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenic alopecia (AGA) is the most common type of hair loss in men, and there are many studies on the treatment of hair loss by platelet\u2010rich plasma (PRP). The human scalp contains a huge microbiome, but its role in the process of hair loss remains unclear, and the relationship between PRP and the microbiome needs further study. Therefore, the purpose of this study was to investigate the effect of PRP treatment on scalp microbiota composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed PRP treatment on 14 patients with AGA, observed their clinical efficacy, and collected scalp swab samples before and after treatment. The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3\u2010V4 region of the 16\u2009s RNA gene and sequencing for bacterial identification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that PRP was effective in the treatment of AGA patients, and the hair growth increased significantly. The results of relative abundance analysis of microbiota showed that after treatment, g_<jats:italic>Cutibacterium<\/jats:italic> increased and g_<jats:italic>Staphylococcus<\/jats:italic> decreased, which played a stable role in scalp microbiota. In addition, g_<jats:italic>Lawsonella<\/jats:italic> decreased, indicating that the scalp oil production decreased after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12414","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:16:56Z","timestamp":1715228216000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet\u2010rich plasma (PRP)"],"prefix":"10.1002","volume":"7","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Life Science Academy  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Hospital of Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Affiliated Hospital of Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hainan Hospital of PLA General Hospital  Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Affiliated Hospital of Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Hou","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy  Beijing China"},{"name":"Department of Chemical Engineering Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1770171"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.178536"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15081"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2017.12.027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13935"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030236"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10834-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12657"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401133300208"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1990.tb01641.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.054"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-009-0793-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac023"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2013.2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01821-12"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24877"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061735"},{"key":"e_1_2_10_21_1","unstructured":"Human microbiome: What's new in scalp diseases. 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